Specifying protein kinase C functions in melanoma

Pigment Cell & Melanoma Research
Mitchell F Denning

Abstract

The protein kinase C (PKC) family of serine/threonine protein kinases is a heterogeneous group of enzymes receiving and integrating signals involved in both normal melanocyte biology and melanoma pathology. Alterations in PKC enzyme expression and activation contribute to the malignant phenotype of melanoma in both oncogenic and tumor suppressive roles. Delineating the diverse and often context-dependent functions of PKC enzymes in melanocyte/melanoma biology is key to capitalize on these kinases as drug targets. This review summarizes several of the diverse functions of PKC in melanocyte and melanoma biology with a focus on PKC enzyme regulation and function.

References

Sep 1, 1991·Clinical & Experimental Metastasis·B S SharmaR K Robins
Sep 1, 1989·Journal of Cellular Physiology·M R Pittelkow, G D Shipley
Jan 1, 1983·Carcinogenesis·M EisingerI B Weinstein
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Eisinger, O Marko
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·Y AritaI B Weinstein
Aug 31, 1993·Biochemical and Biophysical Research Communications·S S SinghV P Chauhan
Jun 1, 1996·Journal of Cellular Physiology·M OkaM Ichihashi
Jan 10, 1997·The Journal of Biological Chemistry·K NishikawaL C Cantley
Nov 14, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I GolovlevaE Lundgren
Nov 21, 1998·British Journal of Cancer·D J PropperA L Harris
May 29, 1999·The Journal of Biological Chemistry·H Y ParkB A Gilchrest
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J SzalayR Vazeos
May 3, 2001·Melanoma Research·A Y BedikianT Smith
Jun 2, 2001·The Journal of Biological Chemistry·E G Stebbins, D Mochly-Rosen
Sep 15, 2001·Free Radical Biology & Medicine·F L MeyskensR I Gonzalez
Oct 19, 2001·Oncogene·D Schechtman, D Mochly-Rosen
Feb 22, 2002·Cancer Chemotherapy and Pharmacology·Beverly A TeicherMargaret M Faul
Jun 11, 2002·Biochemical and Biophysical Research Communications·Carla PeregoCaterina A M La Porta
Jun 28, 2002·Cancer Cell·Ashani T WeeraratnaJeffrey M Trent
Dec 24, 2002·The Biochemical Journal·Alexandra C Newton
May 17, 2003·Bioorganic & Medicinal Chemistry Letters·Margaret M FaulMichael Mohr
May 23, 2003·Journal of Biochemistry·Takaaki Hirai, Kazuhiro Chida

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Citations

Mar 25, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S-C JiZ Li
Jul 20, 2013·Pigment Cell & Melanoma Research·Simona RomanoMaria Fiammetta Romano
Mar 26, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·L VannesteM Garmyn
Aug 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katharina LimmAnja-Katrin Bosserhoff
Apr 22, 2017·Cancers·Mariana ToricelliMiriam G Jasiulionis
Jul 20, 2016·International Journal of Molecular Sciences·Stacey A N D'MelloMarjan E Askarian-Amiri
Jun 10, 2015·Molecular and Cellular Biology·Robert HooperJonathan Soboloff
Oct 17, 2019·Cancers·Chhanda BoseSanjay Awasthi
Nov 8, 2019·Journal of Cosmetic Dermatology·Yang-Chun XuPing Li
Sep 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Konduru Seetharama SastryAouatef Ismail Chouchane
Jun 17, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·V Cilleros-MañéM A Lanuza
Sep 2, 2021·Pigment Cell & Melanoma Research·Dániel László VidácsZsuzsanna Bata-Csörgő

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