Specimen weight and volume: important predictors of survival in malignant pleural mesothelioma

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Diana Y KirchevaWickii T Vigneswaran

Abstract

The tumour/node/metastasis (TNM) staging system for malignant pleural mesothelioma (MPM) is a worldwide standard, but has many limitations. Tumour volume has been suggested as a predictor of survival. Due to the complex anatomy, estimation of tumour volume via CT scan can be challenging. Surgical volume may be more accurate. Therefore, we prospectively determined resected specimen volumes and weights in consecutive patients undergoing extended pleurectomy and decortication (EPD) and correlated this with overall survival and T and N stage. We evaluated 116 patients undergoing EPD for MPM in a single university centre over a 6-year period. All resected specimens were weighed, and the volume was measured by a fluid displacement method. A Cox regression model was used to identify significant predictors of survival; hazard ratios were calculated. A Kaplan-Meier method was used to summarize overall and subgroup survival. Logistic regression models were used to identify predictors of T and N stage. There were 95 males and 21 females with a median age of 68 range 43-88 years. Forty-one patients had an ECOG performance status (PS) 0, 70 had 1 and 4 had 2. The median time between initial diagnosis and surgery was 134 days. Histology was ...Continue Reading

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Citations

Jan 24, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·David A Waller
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
May 26, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Isabelle OpitzGiuseppe Cardillo
Jun 8, 2017·Current Opinion in Pulmonary Medicine·David A Waller, Sara Tenconi
May 27, 2020·The European Respiratory Journal·Arnaud ScherpereelPaul Martin Putora
Aug 17, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Theresa A Gelzinis
Mar 21, 2021·Nature Communications·Min ZhangDean A Fennell
Jul 2, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ming-Sound TsaoAaron S Mansfield

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