Speckle reduction in optical coherence tomography by two-step image registration

Journal of Biomedical Optics
Hang ZhangXiangyang Zhang

Abstract

The image quality of optical coherence tomography can be severely influenced by speckle noise (i.e., signal-degrading speckle). Averaging multiple B-scans can effectively suppress speckle noise. Because of sample motion, images subject to averaging must be aligned exactly. We propose a two-step image registration scheme that combines global and local registrations for speckle reduction by the averaging of multiple B-scans. The method begins with a global registration to compensate for overall motion, which is estimated based on the rigid transformation model involving translation and rotation. Then each A-scan is aligned by cross-correlation using a graph-based algorithm, followed by a pixel subdivision method to improve smoothness in local registration. The method does not rely on any information about the retinal layer boundaries. We have applied this method to the registration of macular optical coherence tomography images. The results show the reduction of speckle noise and the enhanced visualization of layer structures. A signal-to-noise ratio improvement of nearly the square root of the number of averaged B-scans and a contrast-to-noise ratio improvement of around 11 are achieved through our method.

References

Nov 22, 1991·Science·D HuangC A Puliafito
Jul 26, 2003·Journal of Biomedical Optics·Michael PircherChristoph K Hitzenberger
Nov 5, 2003·Nature Biotechnology·James G Fujimoto
Feb 21, 2004·Nature Reviews. Neuroscience·Susana Martinez-CondeDavid H Hubel
Apr 21, 2005·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Boris KaramataTheo Lasser
Aug 31, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Aydogan OzcanGuillermo J Tearney
Nov 13, 2007·Journal of Biomedical Optics·Ying T PanCong W Du
May 19, 2009·Optics Letters·Zhongping JianBruce J Tromberg
Jun 3, 2010·Applied Optics·Maciej Wojtkowski
Jul 17, 2010·Optics Letters·Brendan F KennedyDavid D Sampson
Nov 25, 2011·Journal of Biomedical Optics·David Alonso-CaneiroMichael J Collins
Jan 26, 2012·Optics Express·Maciej SzkulmowskiMaciej Wojtkowski
Mar 22, 2012·Biomedical Optics Express·Markus A MayerRalf P Tornow
Jan 1, 1999·Journal of Biomedical Optics·J M SchmittK M Yung
Jan 28, 2014·Biomedical Optics Express·Mitsuro SugitaChristoph K Hitzenberger
Jul 30, 2014·Biomedical Optics Express·Min ChenAaron Carass

❮ Previous
Next ❯

Citations

Mar 27, 2018·Journal of Biomedical Optics·Ashkan AbbasiHossein Rabbani
Nov 9, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yoshitsugu MatsuiHisashi Matsubara
May 9, 2019·Biomedical Optics Express·M Hossein EybposhMohammadreza Nasiriavanaki
Dec 5, 2019·Biomedical Optics Express·Bernhard BaumannChristoph K Hitzenberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.