Abstract
Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ventricular (LV) unloading under mechanical circulatory support. A total of 24 Yorkshire pigs underwent Impella-mediated acute LV unloading 1-2 weeks after myocardial infarction (MI). Echocardiographic and invasive pressure-volume measurements were used to evaluate the degree of LV unloading. Pressure-volume analysis before and after LV unloading exhibited a significant decrease in stroke work (3399 ± 1440 to 1244 ± 659 mmHg ml, p < 0.001), suggesting reduced external cardiac work. Both longitudinal strain (- 14.6 ± 4.1% to - 10.6 ± 2.3%, p < 0.001) and circumferential strain (- 18.7 ± 6.1% to - 9.3 ± 3.5%, p < 0.001) decreased after LV unloading, and there were linear relationships between stroke work and echocardiographic longitudinal (r = - 0.61, p < 0.001) as well as circumferential strains (r = - 0.75, p < 0.001). Echocardiographic LV strain analysis offers a non-invasive assessment of LV unloading in subacute MI.
References
Apr 8, 2003·Journal of the American College of Cardiology·Bart MeynsWillem Flameng
Dec 23, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Andrew T BurnsDavid L Prior
Jan 11, 2012·The International Journal of Cardiovascular Imaging·Kiyotake IshikawaRoger J Hajjar
Mar 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel Burkhoff, Srihari S Naidu
Sep 14, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Kiyotake IshikawaRoger J Hajjar
May 23, 2015·Journal of the American Heart Association·Kiyotake IshikawaRoger J Hajjar
Sep 4, 2015·Artificial Organs·Xiaotian SunChunsheng Wang
Sep 14, 2015·International Journal of Cardiology·Francesco BurzottaJosé P S Henriques
Oct 29, 2015·European Heart Journal·Otto A SmisethStig Urheim
Nov 7, 2015·JACC. Heart Failure·Navin K KapurRichard H Karas
Dec 17, 2015·Journal of the American College of Cardiology·Daniel BurkhoffNir Uriel
Jan 4, 2017·Interactive Cardiovascular and Thoracic Surgery·Paul PerryGary Raff
Feb 9, 2017·Annals of Biomedical Engineering·Kevin G SoucySteven C Koenig
Feb 25, 2017·Journal of the American College of Cardiology·Patrick CollierAllan Klein
Apr 17, 2017·JACC. Cardiovascular Imaging·Karima AddetiaRoberto M Lang
May 10, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Maria PrastaroMaurizio Galderisi
Oct 22, 2017·Journal of the American Heart Association·Sudeep KuchibhotlaNavin K Kapur
Nov 5, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Kiyotake IshikawaRoger J Hajjar
Feb 8, 2018·JACC. Cardiovascular Imaging·Elizabeth Potter, Thomas H Marwick
Mar 9, 2018·Journal of the American Heart Association·Shin WatanabeKiyotake Ishikawa
Citations
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Tadao AikawaKiyotake Ishikawa
Sep 3, 2020·JACC. Basic to Translational Science·Kleiton Augusto Santos Silva, Craig A Emter
Apr 6, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Andrea MontisciFederico Pappalardo
Apr 19, 2021·BMC Cardiovascular Disorders·Christoph NixMatthias Derwall