Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility.

Biomedical Optics Express
David W CadotteVictor X D Yang

Abstract

Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly understood. Here we present work that aims to optimize an in vivo OCT imaging model of the rodent spinal cord. In this study we image the microvascular networks of both rats and mice using speckle variance OCT. This is the first report of depth resolved imaging of the in vivo spinal cord using an entirely endogenous contrast mechanism.

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Citations

Mar 5, 2013·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Xuan LiuJin U Kang
Nov 26, 2015·Biomedical Optics Express·Yuewen WangXuan Liu
Nov 27, 2014·Biomedical Optics Express·Chih-Hsun YangShih-Ming Jung
Jul 9, 2013·Current Opinion in Neurobiology·Yicong WuHari Shroff
Feb 2, 2019·Physics in Medicine and Biology·Anthony J Deegan, Ruikang K Wang
Dec 22, 2016·Physiological Measurement·Marieke A van der PuttenAndrew R Harvey
Aug 29, 2019·Biomedical Engineering Letters·Woo June Choi
Jun 15, 2021·Experimental Biology and Medicine·Arash DadkhahShuliang Jiao

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Methods Mentioned

BETA
confocal microscopy
dissection

Software Mentioned

SV
OCT
CUDA
RevoDrive3

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