SPECT imaging of D2 dopamine receptors and endogenous dopamine release in mice.

European Journal of Nuclear Medicine and Molecular Imaging
Cynthia JongenJan Booij

Abstract

The dopamine D(2) receptor (D2R) is important in the mediation of addiction. [(123)I]iodobenzamide (IBZM), a SPECT ligand for the D2R, has been used for in vivo studies of D2R availability in humans, monkeys, and rats. Although mouse models are important in the study of addiction, [(123)I]IBZM has not been used in mice SPECT studies. This study evaluates the use of [(123)I]IBZM for measuring D2R availability in mice. Pharmacokinetics of [(123)I]IBZM in mice were studied with pinhole SPECT imaging after intravenous (i.v.) injection of [(123)I]IBZM (20, 40, and 70 MBq). In addition, the ability to measure the release of endogenous dopamine after amphetamine administration with [(123)I]IBZM SPECT was investigated. Thirdly, i.v. administration, the standard route of administration, and intraperitoneal (i.p.) administration of [(123)I]IBZM were compared. Specific binding of [(123)I]IBZM within the mouse striatum could be clearly visualized with SPECT. Peak specific striatal binding ratios were reached around 90 min post-injection. After amphetamine administration, the specific binding ratios of [(123)I]IBZM decreased significantly (-27.2%; n = 6; p = 0.046). Intravenous administration of [(123)I]IBZM led to significantly higher spec...Continue Reading

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Citations

May 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·M PissarekN Schramm
Dec 18, 2008·Physics in Medicine and Biology·S ShokouhiT E Peterson
Jun 5, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Monique R BernsenMarion de Jong
Nov 23, 2013·Parkinsonism & Related Disorders·Sven R SuwijnJan Booij
Sep 6, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Elsmarieke van de GiessenJan Booij
Dec 25, 2016·NeuroImage·Stergios TsartsalisPhilippe Millet
Aug 31, 2021·Frontiers in Neuroscience·Susanne NikolausHans-Wilhelm Müller

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