SPECT vs. PET in cardiac innervation imaging: clash of the titans

Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging
Rudolf A WernerTakahiro Higuchi

Abstract

We aim to provide an overview of the conventional single photon emission computed tomography (SPECT) and emerging positron emission tomography (PET) catecholamine analogue tracers for assessing myocardial nerve integrity, in particular focusing on 18F-labeled tracers. Increasingly, the cardiac sympathetic nervous system (SNS) is being studied by non-invasive molecular imaging approaches. Forming the backbone of myocardial SNS imaging, the norepinephrine (NE) transporter at the sympathetic nerve terminal plays a crucial role for visualizing denervated myocardium: in particular, the single-photon-emitting NE analogue 123I-meta-Iodobenzylguanidine (123I-mIBG) has demonstrated favorable results in the identification of patients at a high risk for cardiac death. However, cardiac neuronal PET agents offer several advantages including improved spatio-temporal resolution and intrinsic quantifiability. Compared to their 11C-labeled counterparts with a short half-life (20.4 min), novel 18F-labeled PET imaging agents to assess myocardial nerve integrity have the potential to revolutionize the field of SNS molecular imaging. The longer half-life of 18F (109.8 min) allows for more flexibility in the study design and delivery from central cy...Continue Reading

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Citations

Jan 30, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Anna Teresińska
Oct 20, 2018·The International Journal of Cardiovascular Imaging·Rudolf A WernerTakahiro Higuchi
Jul 25, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xinyu ChenTakahiro Higuchi
Oct 26, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rudolf A Werner
May 31, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Rudolf A WernerTakahiro Higuchi
Jun 20, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rudolf A WernerFrank M Bengel

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