SPECT/CT-plethysmography--non-invasive quantitation of bone and soft tissue blood flow.

Journal of Orthopaedic Surgery and Research
Lior DayanGiris Jacob

Abstract

Preserved blood flow to bone and soft tissue is essential for their normal function. To date only numerous methods are suitable for direct bone blood flow (BBF) measurement. Here, we introduce a novel quantitative method for bone and soft tissue blood flow (BBF and SBF, respectively) measurement. It involves a combination of SPECT/CT imaging for blood pool localization in a specific region of interest ("soft" and "hard" tissues composing a limb) with veno-occlusive plethysmography. Using it, we measured BBF and SBF in the four limbs of 10 healthy subjects. At steady state blood flow measurements in the four limbs were similar, ranging between 5.5-6.5 and 1.87-2.48 ml per 100 ml of tissue per minute for BBF and SBF, respectively. Our results are comparable to those in the literature. We concluded that SPECT/CT-plethysmography appears to be a readily available and easy to use method to measure BBF and SBF, and can be added to the armamentarium of methods for BBF measurements.

References

Jan 11, 1975·IEEE Transactions on Bio-medical Engineering·D E HokansonD E Strandness
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H P NötzliR Wyatt
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M F SwiontkowskiB A Rahn
Jun 1, 1968·The Journal of Bone and Joint Surgery. American Volume·W J Kane
Jun 1, 1968·The Journal of Bone and Joint Surgery. American Volume·S S Shim
Oct 15, 1996·The Journal of Physiology·M RaitakariH Yki-Järvinen
Jun 17, 1999·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·S IidaH Moriya
Nov 21, 2000·Scandinavian Journal of Medicine & Science in Sports·P Nuutila, K Kalliokoski
Jul 17, 2001·Cells, Tissues, Organs·J T FlemingJ B Feitelson
Jul 10, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·Michel Laroche
Aug 22, 2003·Seminars in Nuclear Medicine·Zohar KeidarYodphat Krausz
Oct 2, 2003·Journal of Physiological Anthropology and Applied Human Science·Tiziano BinzoniDelpy Delpy
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michelle L FrostIgnac Fogelman
Nov 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Ian McCarthy

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
x-ray imaging
X-ray

Software Mentioned

Excel
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved