PMID: 8594953Dec 1, 1995Paper

Spectral analysis of arterial pressure lability in rats with sinoaortic deafferentation

The American Journal of Physiology
H J JacobG A Myers

Abstract

Traditionally, the standard deviation (SD) of the mean arterial pressure (AP) has been used as an index for the AP lability produced by interruption of baroreceptor afferents. Although a useful measure of variance about the mean, the SD does not provide any information about the temporal characteristics of this variability. We employed two different spectral analytic techniques to characterize AP waveforms in rats with sinoaortic deafferentation (SAD) and in sham-operated (Sham) rats to determine if the AP waveform in SAD animals was qualitatively and/or quantitatively different from that of Sham animals. The SAD and Sham animals exhibited qualitatively different spectral profiles, suggesting that lability of AP in SAD animals is not simply an exaggeration of normal fluctuations. In addition, a low-frequency (0.3-0.5 Hz) spectral peak was found in Sham but not SAD animals, suggesting that it is associated with the baroreflex. Finally, we observed in both normal rats and rats without intact baroreceptors that the spectral components of AP are not static but rather vary continuously across time.

Citations

Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Simon C Malpas
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huang-Ku LiuSimon C Malpas
Oct 23, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David C RandallDon E Burgess
Jun 14, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Rubens FazanHelio C Salgado
Jan 24, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aso SaeedGregor Guron
Apr 5, 2020·Neural Regeneration Research·George Zaki GhaliEmil Zaki Ghali
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bruce N Van VlietJean-Pierre Montani
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D BertramC Julien
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B R DworkinS Dworkin
Jun 15, 2011·Experimental Physiology·Fernanda Luciano RodriguesRubens Fazan
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B R DworkinX Tang
Mar 20, 2020·International Journal for Numerical Methods in Biomedical Engineering·Luciano G FernandesPablo J Blanco

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