Spectral analysis of bilateral or alternate-site kindling-induced afterdischarges in the rabbit hippocampi

Epilepsy Research
Komei Tsuchiya, Shinichi Kogure

Abstract

Kindling is one of the popular animal models of temporal lobe epilepsy. In the present study following the previous results obtained using unilateral hippocampal kindling (UK), we performed spectral analysis of bilateral or alternate-site kindling-induced afterdischarges (ADs) in the rabbit hippocampi. Eight and ten adult rabbits were used for bilateral kindling (BK) and alternate-site kindling (AK), respectively. Kindling stimuli consisted of a train of biphasic pulses (1ms duration each) of 50Hz for 1s, with suprathreshold intensity for AD. The stimulations were applied simultaneously to the bilateral hippocampi in the BK and were delivered to the right and left hippocampus once every 24h in the AK. Motor responses were classified into five stages according to the conventional criteria. All animals in BK as well as AK developed stage 5 convulsions. This contrasts to the result of UK (kindled: 50%; incomplete: 50%). We normalized power spectral density (PSD) and monitored the changes in the proportion of lower frequency band component (LFB: 0-9Hz) and the higher frequency band (HFB: 12-30Hz). BK animals showed a significantly large decrement (0.5 times, p<0.01) in LFB component at the final stage compared to the initial stage,...Continue Reading

References

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Jun 16, 2007·Epilepsia·Edward Bertram
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tamar DugladzeTengis Gloveli
Dec 6, 2008·Epilepsia·Jerome EngelIstvan Mody
Apr 21, 2009·Epilepsy Research·Alberto E MustoJustin F Hayes

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Citations

Oct 28, 2016·Brain Research Bulletin·Mostafa JalilifarZohreh Ghotbeddin
Jul 5, 2017·Medical & Biological Engineering & Computing·Yu-Lin WangFu-Zen Shaw

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