Spectral characteristics, DNA-binding and cytotoxicity of two functional Ru(II) mixed-ligand complexes

Dalton Transactions : an International Journal of Inorganic Chemistry
Li-Feng TanChao Weng

Abstract

Two functional Ru(II) mixed-ligand complexes, [Ru(phen)(2)(ttbd)](2+) (1) (ttbd = 4-(6-propenyl-pyrido[3,2-a]phenzain-10-yl-benzene-1,2-diamine, phen = 1,10-phenanthroline) and [Ru(bpy)(2)(ttbd)](2+) (2) (bpy = 2,2'-bipyridine), have been synthesized and characterized. The spectral characteristics of complexes 1 and 2 were investigated using fluorescence spectroscopy and revealed that both complexes were very sensitive to solvent polarity and oxygen molecules in nonaqueous solvents. The binding properties of the two complexes towards calf thymus DNA (CT-DNA) were investigated with different spectrophotometric methods, viscosity measurements and quantum chemistry calculations, indicating that both complexes could enantioselectively bind to CT-DNA by means of intercalation, but with different binding strengths and discrimination. On the other hand, the cytotoxicity of both complexes have been evaluated by MTT assays and Giemsa staining experiments. The main results reveal that the hydrophobicity and surface area of the ancillary ligands have a significant effect on their DNA binding behavior and both complexes are likely to be useful for optically probing nonaqueous and oxygen-free environments.

References

Dec 1, 1989·Journal of Inorganic Biochemistry·E Tselepi-Kalouli, N Katsaros
Aug 1, 1965·Journal of Molecular Biology·M J Waring
Nov 1, 1996·Physical Review. a·A Görling
Apr 11, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·X H ZouX Y Li
Dec 26, 2001·Chemical Reviews·E R Jamieson, S J Lippard
Dec 26, 2001·Chemical Reviews·M J ClarkeD R Frasca
Dec 26, 2001·Chemical Reviews·K E ErkkilaJ K Barton
Jul 24, 2003·Chemical Society Reviews·Clive Metcalfe, Jim A Thomas
Oct 8, 2003·Current Pharmaceutical Design·M GalanskiB K Keppler
Mar 23, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anna C G HotzeJan Reedijk
May 24, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuo ShiLiang N Ji
Jun 13, 2006·Journal of Inorganic Biochemistry·Feng GaoLiang-Nian Ji
Jul 31, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Feng GaoLiang-Nian Ji
May 22, 2008·DNA and Cell Biology·Shohreh NafisiHeidar Ali Tajmir-Riahi
Nov 26, 2008·European Journal of Medicinal Chemistry·D Lawrence ArockiasamyBalachandran Unni Nair
Feb 25, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuo ShiLiangnian Ji
Feb 18, 2011·DNA and Cell Biology·Li-Feng TanXi-Ling Ling
Jun 15, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhiming Xu, Shawn Swavey
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Caiping TanAnlong Xu

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Citations

Mar 13, 2014·Journal of Photochemistry and Photobiology. B, Biology·A SrishailamS Satyanarayana
Aug 31, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gan-Jian LinYun-Jun Liu
Mar 8, 2016·Journal of Photochemistry and Photobiology. B, Biology·Shang-Hai LaiYun-Jun Liu
Mar 24, 2016·The Journal of Membrane Biology·Jian-Wei ZhuQi-Feng Guo
Apr 24, 2016·Journal of Photochemistry and Photobiology. B, Biology· N Deepika S Satyanarayana
Jan 23, 2014·European Journal of Medicinal Chemistry·Antonio RescifinaAntonino Corsaro
Jun 12, 2016·Journal of Photochemistry and Photobiology. B, Biology·Chuan-Chuan ZengYun-Jun Liu
Feb 13, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Mani AlagesanNallasamy Dharmaraj
Jul 8, 2017·Journal of Chemical Biology·T Daniel Prakash, V Violet Dhayabaran
Jul 1, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ruihao LiYun Lin
Aug 2, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Holly van der SalmKeith C Gordon
Jun 3, 2021·Pharmaceutics·Arya BhushanJyothi U Menon

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