Spectral editing technique for the in vitro and in vivo detection of taurine

Journal of Magnetic Resonance
D L Hardy, T J Norwood

Abstract

In vivo 1H NMR spectroscopy has proven to be a useful noninvasive tool for the investigation of numerous metabolic and physiological states. Taurine is potentially a useful indicator in neonate development and is involved in a number of physiological processes. However, it could not previously be observed in the in vivo 1H spectrum because of overlap with adjacent resonances. We have developed a spectral editing technique based upon double quantum filtration which allows the taurine resonances to be resolved from adjacent peaks. The experiment is demonstrated both on perchloric acid rodent brain extract and on rodent brain homogenate.

Citations

Apr 2, 2009·The Review of Scientific Instruments·Fumio HoboHideaki Maeda
Dec 31, 2016·Analytical Biochemistry·Wolfgang BognerOvidiu C Andronesi
Apr 10, 2010·The European Journal of Neuroscience·Véronique PabanBéatrice Alescio-Lautier
Mar 31, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yohan van de LooijStéphane V Sizonenko
Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H Lei, J Peeling
Jun 22, 2000·NMR in Biomedicine·V GovindarajuA A Maudsley
Sep 19, 2020·NMR in Biomedicine·In-Young ChoiRobin A de Graaf

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