Spectral filtering for improved pulsed photothermal temperature profiling in agar tissue phantoms.

Journal of Biomedical Optics
Matija MilanicJ S Nelson

Abstract

We present a systematic experimental comparison of pulsed photothermal temperature profiling utilizing the customary spectral band of the InSb radiation detector (lambda=3.0 to 5.6 microm) and a narrowed acquisition band (4.5 to 5.6 microm). We use custom tissue phantoms composed of agar gel layers separated by thin absorbing layers. The laser-induced temperature profiles are reconstructed within the customary monochromatic approximation, using a custom minimization algorithm. In a detailed numerical simulation of the experimental procedure, we consider several acquisition spectral bands with the lower wavelength limit varied between 3.0 and 5.0 microm (imitating application of different long-pass filters). The simulated PPTR signals contain noise with amplitude and spectral characteristics consistent with our experimental system. Both experimental and numerical results indicate that spectral filtering reduces reconstruction error and broadening of temperature peaks, especially for shallower and more complex absorbing structures. For the simulated PPTR system and watery tissues, numerical results indicate an optimal lower wavelength limit of 3.8 to 4.2 microm.

References

Jul 1, 1995·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·T E MilnerJ S Nelson
Oct 2, 1998·Physics in Medicine and Biology·D J SmithiesJ S Nelson
Jul 11, 2002·Physics in Medicine and Biology·Boris MajaronJ Stuart Nelson
May 25, 2007·Lasers in Medical Science·Matija MilanicJ Stuart Nelson
Jan 10, 2008·Physics in Medicine and Biology·Boris Majaron, Matija Milanic
May 1, 1993·Applied Optics·S L JacquesT E Milner
Jul 1, 1997·Journal of Biomedical Optics·U S Sathyam, S A Prahl

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Citations

Jan 12, 2010·Journal of Biomedical Optics·Matija Milanic, Boris Majaron

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