Spectral karyotyping (SKY) of mouse meiotic chromosomes

Genome Génome / Conseil National De Recherches Canada
H H HengP B Moens

Abstract

The spectral karyotyping procedure of in situ hybridization with chromosome-specific probes assigns a unique colour code to each of the 21 mouse mitotic chromosomes. We have adapted this procedure to meiotic prophase chromosomes, and the results show that each of the pachytene or metaphase I bivalents can be identified. This technique has the potential to recognize synaptic anomalies and chromosome-specific structural and behavioural characteristics. We confirm these potentials by the recognition of the heterologous synapsis of the X and Y chromosomes and by the variances of synaptonemal complex lengths for each of the colour-coded bivalents in eight prophase nuclei.

Citations

Jan 15, 2004·Cell & Chromosome·Henry HQ HengChristine J Ye
Jun 14, 2013·Human Pathology·Shantashri VaidyaBabu Rao Vundinti
Dec 31, 2008·Journal of Cellular Physiology·Christine J YeHenry H Q Heng
May 12, 2006·Journal of Cellular Physiology·Henry H Q HengChristine J Ye
May 6, 2006·Journal of Cellular Biochemistry·Henry H Q HengChristine J Ye
Mar 10, 2010·Journal of Cellular Biochemistry·Henry H Q HengChristine J Ye
Nov 15, 2002·American Journal of Human Genetics·Lutz FroenickeTerry Ashley
Dec 5, 2013·Cell Cycle·Guo LiuHenry H Heng
Sep 7, 2006·Cytogenetic and Genome Research·C J YeH H Q Heng
Aug 1, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Trude Schwarzacher
Dec 10, 2003·Genome Génome / Conseil National De Recherches Canada·Hans de Jong
Oct 6, 2005·Cancer Research·Kate C ShenY Alan Wang
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hector BiliranJoshua D Liao
Feb 20, 2004·American Journal of Human Genetics·Fei SunRenée H Martin

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