Spectral modeling for accelerated pH spectroscopy using EPR.

Journal of Magnetic Resonance
Rizwan AhmadValery V Khramtsov

Abstract

A data modeling and processing method for electron paramagnetic resonance (EPR)-based pH spectroscopy is presented. The proposed method models the EPR spectrum of a pH-sensitive probe in both protonated and unprotonated forms. Under slow-exchange conditions, the EPR spectrum of a sample with an unknown pH value can be accurately represented by a weighted sum of the two models, with the pH value completely determined by their relative weights. Unlike traditional pH spectroscopy, which relies on locating resonance peaks, the proposed modeling-based approach utilizes the information from the entire scan and hence leads to more accurate estimation of pH for a given acquisition time. By employing the proposed methodology, we expect a reduction in the pH estimation error by more than a factor of three, which represents an order of magnitude reduction in acquisition time compared to the traditional method.

References

Jan 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B GallezH M Swartz
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B GallezH M Swartz
May 26, 1999·Journal of Magnetic Resonance·B H RobinsonA W Reese
Nov 28, 2001·Clinical Physiology·J H PinkneyJ S Yudkin
Sep 26, 2002·Journal of Critical Care·Carla ChruschSteven N Mink
Dec 21, 2002·Radiation Research·Heon Joo ParkEun Kyung Choi
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Natarajan RaghunandRobert J Gillies
May 14, 2004·Journal of Magnetic Resonance·Yuanmu DengJay L Zweier
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Giovanna KoukoulisThomas M Egan
Feb 6, 2007·Journal of Magnetic Resonance·Subhojit SomPeriannan Kuppusamy
Mar 29, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Michael Riediker, Brigitta Danuser
Aug 2, 2007·Organic Letters·Stuart T CaldwellRichard C Hartley
Jun 21, 2008·Biomacromolecules·Yannie ChanVolga Bulmus
Jan 23, 2009·Journal of Magnetic Resonance·Fuminori HyodoMurali C Krishna
Jul 18, 2009·Methods in Molecular Biology·Nadeem Khan, Dipak K Das
Oct 21, 2009·Biomedizinische Technik. Biomedical Engineering·Sebastian VogtRainer Moosdorf
Jul 10, 2008·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Boris EpelHoward J Halpern
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Sep 21, 2010·Journal of Magnetic Resonance·R AhmadJ L Zweier
Nov 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrey A BobkoValery V Khramtsov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.