Spectral profiles of complex fractionated atrial electrograms are different in longstanding and acute onset atrial fibrillation atrial electrogram spectra.

Journal of Cardiovascular Electrophysiology
Edward J CiaccioHasan Garan

Abstract

Spectral Profiles of CFAE. Spectral analysis of complex fractionated atrial electrograms (CFAE) may be useful for gaining insight into mechanisms underlying paroxysmal and longstanding atrial fibrillation (AF). The commonly used dominant frequency (DF) measurement has limitations. CFAE recordings were acquired from outside the 4 pulmonary vein ostia and at 2 left atrial free wall sites in 10 paroxysmal and 10 persistent AF patients. Two consecutive 8s-series were analyzed from recordings >16s in duration. Power spectra were computed for each 8s-series in the range 3-12 Hz and normalized. The mean and standard deviation of normalized power spectra (MPS and SPS, respectively) were compared for paroxysmal versus persistent CFAE. Also, the DF and its peak amplitude (ADF) were compared for pulmonary vein sites only. Power spectra were computed using ensemble average and Fourier methods. No significant changes occurred in any parameter from the first to second recording sequence. For both sequences, MPS and SPS were significantly greater, and DF and ADF were significantly less, in paroxysmals versus persistents. The MPS and ADF measurements from ensemble spectra produced the most significant differences in paroxysmals versus persiste...Continue Reading

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Citations

Dec 12, 2012·Computers in Biology and Medicine·Jorge Mateo, José Joaquín Rieta
Jul 17, 2013·Biomedical Engineering Online·Edward J CiaccioHasan Garan
Jun 3, 2014·Biomedical Engineering Online·Edward J CiaccioHasan Garan
Jul 19, 2014·Computer Methods and Programs in Biomedicine·Edward J CiaccioHasan Garan
Jun 21, 2014·Journal of Cardiovascular Electrophysiology·Jin WiBoyoung Joung
Sep 4, 2013·Pacing and Clinical Electrophysiology : PACE·Edward J CiaccioHasan Garan
Sep 17, 2013·Pacing and Clinical Electrophysiology : PACE·Edward J CiaccioHasan Garan
Mar 31, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Angelo B BivianoHasan Garan
Sep 17, 2013·Computers in Biology and Medicine·Edward J CiaccioHasan Garan
Jun 22, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Gong LongWang Zhenhu
Jul 10, 2016·Computers in Biology and Medicine·Edward J CiaccioHasan Garan
May 26, 2018·PLoS Computational Biology·Caroline H RoneyEdward J Vigmond

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