Spectral representation of reduced protein models

SAR and QSAR in Environmental Research
M RandićD Plavsić

Abstract

We consider a spectrum-like two-dimensional graphical representation of proteins based on a reduced protein model in which 20 amino acids are grouped into five classes. This particular grouping of amino acids was suggested by Riddle and co-workers in 1997. The graphical representation is based on depicting sequentially the amino acids on five horizontal lines at equal separations. One-letter codes, B, O, U, X and Y, to which numerical values 1 to 5 have been assigned, are suggested as labels for the fictional amino acids that represent all the amino acids within each group. The approach is illustrated on ND6 proteins of eight species having from 168 to 175 amino acids. While visual inspection of the novel spectral graphical representations of proteins may reveal local similarities and dissimilarities of protein sequences, arithmetic manipulations of spectra offer an elegant route to graphic visualization of the degree of similarity for selected pairs of proteins.

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Apr 6, 2005·Journal of Chemical Information and Modeling·Jure Zupan, Milan Randić
Dec 13, 2006·SAR and QSAR in Environmental Research·M RandićD Plavsić
Jan 16, 2007·Journal of Molecular Graphics & Modelling·Milan RandićDrazen Vikić-Topić
May 20, 2008·SAR and QSAR in Environmental Research·M Novic, M Randic

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Citations

Mar 22, 2012·SAR and QSAR in Environmental Research·M RandićD Plavšić
Dec 23, 2014·Computational and Mathematical Methods in Medicine·Lei WangJinhua Zheng
May 5, 2012·Journal of Theoretical Biology·Ping-an HeYuhua Yao
Aug 10, 2010·Journal of Theoretical Biology·Dorota Bielińska-Waz, Shankar Subramaniam
Jun 15, 2010·Journal of Theoretical Biology·Milan RandićDejan Plavsić
Feb 14, 2012·Computers in Biology and Medicine·Zhao-Hui QiLing Li
Oct 14, 2010·Chemical Reviews·Milan RandićDejan Plavsić

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