Spectral, thermal and in vitro antimicrobial studies of cyclohexylamine-N-dithiocarbamate transition metal complexes

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Saul M MambaElvis Fosso-Kankeu

Abstract

Transition metal complexes of the type [M(L)(2)] and those containing monodentate phosphines of the type [M(L)(2)(PPh(3))] {M=Ni, Co, Cu and Zn; L=cyclohexylamine-N-dithiocarbamate; PPh(3)=triphenylphosphine} have been synthesized. The complexes were characterized using IR, UV-vis, NMR spectroscopy, and thermal analysis (TGA). The (1)H NMR, (13)C NMR and (31)P NMR showed the expected signals for the dithiocarbamate and triphenylphosphine moieties. The spectral studies in all compounds revealed that the coordination of metals occurs via the sulphur atom of the dithiocarbamate ligand in a bidentate fashion. Thermal behavior of the complexes showed that the complexes were more stable than their parent ligands. The ligand moiety is lost in the first step and the rest of the organic moiety decomposes in the subsequent steps. Furthermore, the ligand and their metal complexes were screened in vitro for their antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Enterococcus faecalis, Pseudomonas aeruginosa and Bacillus cereus and antifungal activities against Aspergillus flavus, Aspergillus carbonarius, Aspergillus niger and Aspergillus fumigatus. The metal complexes exhibited higher antimicrobial a...Continue Reading

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Citations

Jun 2, 2016·Critical Reviews in Food Science and Nutrition·J A AdebiyiE Kayitesi
Oct 31, 2015·Critical Reviews in Food Science and Nutrition·O A AdeboV Mavumengwana
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jerry O Adeyemi, Damian C Onwudiwe
Aug 10, 2021·Frontiers in Chemistry·Sharifah Nadhira Syed AnnuarKok Meng Chan

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