PMID: 16615189Apr 18, 2006Paper

Spectrometric determination of the refractive index of optical wave guiding materials used in lab-on-a-chip applications

Applied Spectroscopy
Andres M Cardenas-ValenciaLarry Langebrake

Abstract

The design and optimization of light-based analytical devices often require optical characterization of materials involved in their construction. With the aim of benefiting lab-on-a-chip applications, a transmission spectrometric method for determining refractive indices, n, of transparent solids is presented here. Angular dependence of the reflection coefficient between material-air interfaces constitutes the basis of the procedure. Firstly, the method is studied via simulation, using a theoretical algorithm that describes the light propagation through the sample slide, to assess the potentially attainable accuracy. Simulations also serve to specify the angles at which measurements should be taken. Secondly, a visible light source and an optical fiber spectrometer are used to perform measurements on three commonly used materials in optical lab-on-a-chip devices. A nonlinear regression subroutine fits experimental data to the proposed theoretical model and is used to obtain n. Because the attainable precision using this method of refractive index determination is dictated by the uncertainty in the transmission measurements, the precision (with 95% confidence) for mechanically rigid samples, namely glass and poly(methyl methacry...Continue Reading

References

Oct 1, 1989·The British Journal of Dermatology·H B RasmussenF Brandrup
Oct 11, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Katri HuikkoTapio Kotiaho
Apr 22, 2004·Lab on a Chip·S MetzP Renaud
Dec 1, 1998·Analytical Chemistry·D C DuffyG M Whitesides

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Citations

May 21, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Abhijit Chandra RoyAnimangsu Ghatak

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