Spectrophotometric and AAS determination of ramipril and enalapril through ternary complex formation

Journal of Pharmaceutical and Biomedical Analysis
Magda M AyadMervat M Hosny

Abstract

Two sensitive, spectrophotometric and atomic absorption spectrometric procedures are developed for the determination of two antihypertensive agents (enalapril maleate and ramipril). The spectrophotometric procedures for the two cited drugs are based on ternary complex formation. The first ternary complex (copper(II), eosin, and enalapril) was estimated by two methods; the first depends on its extraction with chloroform measuring at 533.4 nm. Beer's law was obeyed in concentration range from 56 to 112 microg ml(-1). The second method for the same complex depends on its direct measurement after addition of methylcellulose as surfactant at the pH value 5 at 558.8 nm. The concentration range is from 19 to 32 microg ml(-1). The second ternary complex (iron(III), thiocyanate, and ramipril) was extracted with methylene chloride, measuring at 436.6 nm, with a concentration range 60-132 microg ml(-1). The direct atomic absorption spectrometric method through the quantitative determination of copper or iron content of the complex was also investigated for the purpose of enhancing the sensitivity of the determination. The spectrophotometric and atomic absorption spectrometric procedures hold their accuracy and precision well when applied ...Continue Reading

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Citations

Dec 16, 2005·AAPS PharmSciTech·Nafisur RahmanSyed Najmul Hejaz Azmi
Dec 17, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Tamer Z Attia, Mahmoud A Omar
Sep 15, 2005·Biomedical Chromatography : BMC·R BhushanShravan Kumar Singh
Feb 9, 2010·International Journal of Analytical Chemistry·Hassan AridaAbdallah Ali
Mar 1, 2003·Analytical and Bioanalytical Chemistry·Magda M AyadMervat M Hosny
Nov 10, 2004·Journal of Pharmaceutical and Biomedical Analysis·Raluca-Ioana StefanHassan Y Aboul-Enein
Mar 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Ariana ZoppiMarcela Longhi
Nov 4, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Muhammad N KhanMuhammad Mursaleen
Jul 29, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hisham E Abdellatef

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