Spectrophotometric and electrical studies of charge-transfer complexes of sodium flucloxacillin with pi-acceptors

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Moamen S Refat, Akram M El-Didamony

Abstract

The present study is interested to develop a simple, rapid and accurate spectrophotometric method for determination of sodium flucloxacillin (fluc) in pure form and pharmaceutical formulations. The charge-transfer (CT) interactions between sodium flucloxacillin as electron donor and chloranilic acid (CLA), dichloroquinone 4-chloroimide (DCQ), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 7,7,8,8 tetracyano-p-quinodimethane (TCNQ), as pi-electron acceptors have been investigated spectrophotometrically. Different variables affecting the reaction were studied and optimized. Under the optimum conditions, linear relationships with good correlation coefficients (0.9979-0.9995) were found between the absorbance and the concentration of the drug in the range 16-880 microg ml(-1). The proposed methods were applied successfully to the determination of the examined drug either in pure or pharmaceutical dosage forms with good accuracy and precision. The formation of the CT-complexes and the sites of interaction were confirmed by elemental analysis CHN, UV-vis, IR, (1)H NMR and mass spectra techniques. Based on Job's method of continuous variation plots, the obtained results indicate the formation of 1:1 charge-transfer complexes with t...Continue Reading

Citations

Dec 15, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gururaj M NeelgundM L Budni
Mar 17, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M Pandeeswaran, K P Elango
Mar 8, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Khalid A M AttiaAhmed Serag
Aug 28, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zeynep Aydoğmuş
Aug 22, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Moamen S RefatIvo Grabchev
May 6, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Silvia BertoMery Malandrino
May 31, 2018·Critical Reviews in Analytical Chemistry·Mariana Nunes de MenezesHérida Regina Nunes Salgado

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