Spectrophotometric determination of acidity constants by two-rank annihilation factor analysis

Analytica Chimica Acta
B HemmateenejadAlireza Foroumadi

Abstract

Annihilation of the contribution of one chemical component from the original data matrix is a general method in rank annihilation factor analysis (RAFA). However, RAFA is not applicable for studying the protonation equilibria of multiprotic acids. In this work, a two-rank annihilation factor analysis (TRAFA) method was proposed for determination of the acidity constants of diprotic acids. After recording the electronic absorbance spectra of the acids at different pH, the contributions of both H(2)A and A(2-) were annihilated from the absorbance data, which made feasible the determination of two successive acidity constants. The method was validated by analysis of simulated data and its application to the determination of the acidity constants of calmagite, as a reference compound. A close agreement was obtained between the resulted values by TRAFA and the declared values. Indeed, the method was used for determination of the acidity constants of two new chromenone derivatives in binary solvents mixtures of methanol and water. The effects of changing solvent composition on acidity constant data were explained by linear solvation free energy relationships (LSFER) utilizing solvatochromic parameters.

References

Jan 1, 1960·The International Journal of Applied Radiation and Isotopes·J R GUTMANN
Jun 25, 2004·Journal of Chromatography. a·Salwa K PooleColin F Poole

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Citations

Nov 3, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jahan B Ghasemi, Ali R Jalalvand
Dec 17, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Bahram HemmateenejadHashem Sharghi
Apr 21, 2011·Analytica Chimica Acta·Hamid Abdollahi, Azadeh Golshan
Jun 26, 2012·Journal of Pharmaceutical and Biomedical Analysis·Fatemeh Ghasemi MoghaddamSomayeh Gholami
Jun 25, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zolaikha Rasouli, Raouf Ghavami
Jul 28, 2016·Journal of Molecular Modeling·Z N Cisneros-GarcíaJ G Rodríguez-Zavala
Mar 28, 2013·Cancer Causes & Control : CCC·Hugo Deneo-PellegriniMaría E Luaces

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