PMID: 16512429Mar 4, 2006Paper

Spectrophotometric determination of anthracycline anticancer agents with aluminum(III) and chromazurol S in a nonionic surfactant micellar medium

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Masahiro NakaoYoshikazu Fujita

Abstract

A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 x 10(5) dm3 mol(-1) cm(-1) at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 microg ml(-1) for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.

References

Nov 1, 1972·Clinical Pharmacology and Therapeutics·D H HuffmanN R Bachur
Mar 9, 1984·Journal of Chromatography·M J OosterbaanE van der Kleijn
Mar 16, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·F LachâtreJ L Dupuy
Nov 1, 1996·Talanta·C S Sastry, J S Lingeswara Rao

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Citations

Dec 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kanako MiyachiYoshikazu Fujita

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