PMID: 15356997Sep 11, 2004Paper

Spectrophotometric determination of nizatidine and ranitidine through charge transfer complex formation

Archives of Pharmacal Research
M WalashM RedaShabana

Abstract

Two Spectrophotometric procedures are presented for the determination of two commonly used H2-receptor antagonists, nizatidine (I) and ranitidine hydrochloride (II). The methods are based mainly on charge transfer complexation reaction of these drugs with either p-chloranilic acid (rho-CA) or 2, 3 dichloro-5, 6-dicyanoquinone (DDQ). The produced colored products are quantified spectrophotometrically at 515 and 467 nm in chloranilic acid and DDQ methods, respectively. The molar ratios for the reaction products and the optimum assay conditions were studied. The methods determine the cited drugs in concentration ranges of 20-200 and 20-160 microg/mL for nizatidine and ranges of 20-240 and 20-140 microg/mL for ranitidine with chloranilic acid and DDQ methods, respectively. A more detailed investigation of the complexes formed was made with respect to their composition, association constant, molar absorptivity and free energy change. The proposed procedures were successfully utilized in the determination of the drugs in pharmaceutical preparations. The standard addition method was applied by adding nizatidine and ranitidine to the previously analyzed tablets or capsules. The recovery of each drug was calculated by comparing the conc...Continue Reading

References

Aug 1, 1984·Australian and New Zealand Journal of Medicine·C E GrimJ C Christian
Oct 30, 2001·Journal of Pharmaceutical and Biomedical Analysis·E M Hassan, F Belal
Oct 18, 2002·Journal of Clinical Pharmacy and Therapeutics·M I WalashM Eid

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Citations

Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·B RezaeiA A Ensafi
Jul 10, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Mahmut B Çakar, Sevgi T Ulu
May 6, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Maha F Abdel-GhanyYomna Y Mohammed

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