Spectrophotometric determination of paracetamol with microwave assisted alkaline hydrolysis

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Chunli Xu, Baoxin Li

Abstract

A novel and rapid spectrophotometric method for the determination of paracetamol is proposed in this paper. The proposed method is based on the microwave assisted alkaline hydrolysis of paracetamol to p-aminophenol that reacts with S2- in the presence of Fe3+ as oxidant to produce a methylene blue-like dye having an absorptivity maximum at 540 nm. The experiment showed that paracetamol could be hydrolysed quantitatively to p-aminophenol in only 1.5 min under radiation power 640 W using a microwave in NaOH medium. The system obeys Beer's law in the range of 0-3.0 x 10(-4) mol l(-1) paracetamol. The molar absorptivity and Sandell's sensitivity were found to be 3.2 x 10(-3) l mol(-1) cm(-1) and 0.047 microg cm(-2), respectively. The relative standard deviation (n=11) was 1.7% for 8.0 x 10(-5) mol l(-1) paracetamol. The method has been applied successfully to analysis of paracetamol in pharmaceutical preparation.

Citations

May 24, 2006·Journal of Pharmaceutical and Biomedical Analysis·M Espinosa BoschC Bosch Ojeda
Jul 11, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A S El-ShahawyN Kh Sayed
Aug 8, 2018·ACS Applied Materials & Interfaces·Mattia Alberto LucchiniGustav Nyström

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