Spectroscopic and cytotoxic studies of the novel designed palladium(II) complexes: beta-lactoglobulin and K562 as the targets

International Journal of Biological Macromolecules
Adeleh DivsalarH Mansoori-Torshizi

Abstract

Since palladium complexes have been reported to show fewer side effects relative to other heavy metal anticancer compounds, in this study a new class of four structurally related anticancer Pd(II) complexes including 2,2'-bipyridin-n-butyl dithiocarbamato Pd(II) nitrate (Com-1), 2,2'-bipyridin-n-hexyl dithiocarbamato Pd(II) nitrate (Com-2), 2,2'-bipyridin glycinato Pd(II) nitrate (Com-3) and 2,2'-bipyridin octylglycinato Pd(II) nitrate (Com-4) was designed. The effect of four synthesized ligands on the protein structure and cell proliferation were investigated. Whey carrier proteins beta-lactoglobulin-A and-B (BLG-A and-B) and chronic myelogenous leukemia cell line K562 were the targets. Fluorescence and CD instruments were used to assess effect of the ligands on the protein structure. Growth inhibitory effect of the Pd(II) complexes towards the cancer cells was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Results of fluorescence studies revealed that the complexes had no dithiocarbamate moiety (compounds 3 and 4) could quench the intrinsic fluorescence emission of the proteins at lower concentrations than those had such moiety (compounds 1 and 2). The far-UV-CD studies revealed that...Continue Reading

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Citations

Jul 26, 2011·Nucleosides, Nucleotides & Nucleic Acids·H Mansouri-TorshiziA A Saboury
Sep 6, 2014·Journal of Photochemistry and Photobiology. B, Biology·Behafarid GhalandariKazem Parivar
Sep 14, 2013·Colloids and Surfaces. B, Biointerfaces·Mohammad Hossein MehrabanAli Khalafi-Nezhad
Sep 14, 2013·Colloids and Surfaces. B, Biointerfaces·Mahdieh RazmiHassan Mansuri-Torshizi
Jun 13, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mohammad Bagher ShahsavaniReza Yousefi
Aug 27, 2016·Journal of Biomolecular Structure & Dynamics·Mohammad AminzadehAli Reza Modarresi-Alam
Aug 27, 2016·Journal of Biomolecular Structure & Dynamics·Mohammad Hossein MehrabanYounes Ghasemi
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mohammad Bagher ShahsavaniReza Yousefi
Apr 25, 2017·Journal of Biomolecular Structure & Dynamics·Sareh Zareian-Jahromi, Hassan Mansouri-Torshizi
Dec 1, 2017·Nucleosides, Nucleotides & Nucleic Acids·Mahboube Eslami MoghadamSoheila Sanati
Aug 30, 2017·Journal of Biomolecular Structure & Dynamics·Hassan Mansouri-TorshiziMostafa Heidari Majd
Aug 28, 2018·Journal of Biomolecular Structure & Dynamics·Behafarid GhalandariAli Akbar Saboury
Oct 31, 2008·Chemistry & Biodiversity·Flávia C S de PaulaElene C Pereira-Maia
Oct 18, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Vaishali VajpayeeKi-Whan Chi
Aug 31, 2011·Journal of Biomolecular Structure & Dynamics·Adeleh DivsalarRamaswamy H Sarma
Nov 19, 2014·Cell Biochemistry and Biophysics·Adeleh DivsalarFaizan Ahmad
Dec 10, 2016·Applied Biochemistry and Biotechnology·Maryam HeydariHossein Farhangian
Mar 24, 2020·Journal of Biomolecular Structure & Dynamics·Azadeh MohammadgholiMahboubeh Eslami-Moghadam
Dec 3, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehran Feizi-DehnayebiHassan Mansouri-Torshizi
May 26, 2009·Journal of Chemical Information and Modeling·Pablo D Dans, E Laura Coitiño
Feb 24, 2010·The Journal of Physical Chemistry. B·Adeleh DivsalarFaizan Ahmad
Jun 19, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hassan Mansouri-TorshiziAli Akbar Saboury

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