Spectroscopic characterizations and biological studies on newly synthesized Cu(2+) and Zn(2+) complexes of first and second generation dendrimers

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Moamen S RefatSamir El-Ghol

Abstract

The novel Cu(II) and Zn(II) complexes of first and second generation poly(propylene amine) dendrimers (PPA), comprising 1,8-naphthalimde units on periphery have been synthesized. These new complexes were characterized by elemental analysis, molar conductivity, spectral methods (IR, (1)H NMR and UV-vis spectra) and thermal analysis (TG and DTG) techniques. From elemental analysis as well as thermal studies it has found that the first generation dendrimer behaves as bidentate ligand and forming chelates with 1:2 (ligand:metal) and 1:4 (ligand:metal) stoichiometry for second generation dendrimer. Different kinetic parameters namely activation energy (DeltaE*), enthalpy of activation (DeltaH*), entropy of activation (DeltaS*) and free energy change of activation (DeltaG*) are calculated using Coats-Redfern equation. The antibacterial activity of dendrimers and their complexes was evaluated against some Gram positive and negative bacteria.

References

Apr 13, 2001·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·G G Mohamed
May 14, 2004·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Fernando PinaHassan Fakhrnabavi

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Citations

Aug 24, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Paweł SzymańskiElżbieta Mikiciuk-Olasik
Oct 5, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sadeek A SadeekMohamed S El-Attar
Nov 4, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mohammad DodangehMokhtar Arami
Dec 5, 2013·Pharmaceutical Development and Technology·Rahul S KalhapureThirumala Govender
Dec 15, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Can-liang FangDi-hua Shangguan
Jul 23, 2013·International Journal of Pharmaceutics·Rahul S Kalhapure, Krishnacharya G Akamanchi
Mar 7, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Sandra García-GallegoF Javier de la Mata

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