Spectroscopic evidence of hippocampal abnormalities in neocortical epilepsy.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
S G MuellerM W Weiner

Abstract

Lesional neocortical epilepsy (NE) can be associated with hippocampal sclerosis or hippocampal spectroscopic abnormalities without atrophy (dual pathology). In this study, magnetic resonance spectroscopic imaging (MRSI) was used to determine the frequency of hippocampal damage/dysfunction in NE with and without structural lesion. Sixteen patients with NE [seven temporal NE (NE-T), nine extratemporal (NE-ET)] and 16 controls were studied with a 2D MRSI sequence (Repetition time/echo time (TR/TE) = 1800/135 ms) covering both hippocampi. Seven NE patients had MR visible lesions (NE-Les), nine had normal MRI (NE-no). In each hippocampus, 12 voxels were uniformly selected. In controls, mean (+/- SD) NAA/(Cr + Cho) values for each voxel were calculated and voxels with NAA/(Cr + Cho) < or = (mean in controls--2SD in controls) were defined as 'pathological' in patients. Eight of 16 NE patients had at least two 'pathological' voxel (mean 2.5, range 2-5) in one hippocampus. Four were NE-Les and four NE-no. Three (43%) NE-T patients, had evidence for hippocampal damage/dysfunction and five (56%) had NE-ET. The ipsilateral hippocampus was affected in six of eight NE patients. Evidence for unilateral hippocampal damage/dysfunction was demon...Continue Reading

References

Jan 1, 1992·Magnetic Resonance Imaging·A A MaudsleyM W Weiner
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J SoherA A Maudsley
Jun 4, 1999·Brain : a Journal of Neurology·L M LiD L Arnold
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J L RoffmanD R Weinberger
Jun 14, 2003·Brain : a Journal of Neurology·Rod C ScottAlan Connelly

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Citations

May 8, 2014·PloS One·Naohide YamamotoAnthony J Caputy
Apr 18, 2008·Neuro-Chirurgie·A Rougier
Oct 6, 2016·Epilepsy Research and Treatment·Marcus C NgAndrew J Cole
Nov 17, 2020·Frontiers in Veterinary Science·Agnieszka OlszewskaMarcin Adam Wrzosek

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