Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range

Journal of Biomedical Optics
Thomas J AllenPaul Beard


Spectroscopic photoacoustic imaging has the potential to discriminate between normal and lipid-rich atheromatous areas of arterial tissue by exploiting the differences in the absorption spectra of lipids and normal arterial tissue in the 740 to 1400 nm wavelength range. Identification of regions of high lipid concentration would be useful to identify plaques that are likely to rupture (vulnerable plaques). To demonstrate the feasibility of visualizing lipid-rich plaques, samples of human aortas were imaged in forward mode, at wavelengths of 970 and 1210 nm. It was shown that the structure of the arterial wall and the boundaries of lipid-rich plaques obtained from the photoacoustic images were in good agreement with histology. The presence of lipids was also confirmed by comparing the photoacoustic spectra (740 to 1400 nm) obtained in a region within the plaque to the spectral signature of lipids. Furthermore, a lipid-rich plaque was successfully imaged while illuminating the sample through 2.8 mm of blood demonstrating the possibility of implementing the photoacoustic technique in vivo.


Jul 1, 1986·The Journal of Clinical Investigation·M R PrinceA R Oseroff
Dec 31, 1997·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·A M NilssonS Andersson-Engels
Nov 11, 1998·Ultrasound in Medicine & Biology·Y SaijoM Tanaka
Sep 23, 2000·Nature·A J Lusis
Mar 10, 2001·Cell·C K Glass, J L Witztum
Aug 18, 2001·Circulation Research·Z A Fayad, V Fuster
Feb 19, 2002·Journal of the American College of Cardiology·Ik-Kyung JangGuillermo J Tearney
Apr 17, 2002·Journal of the American College of Cardiology·Jing WangWard Casscells
Sep 25, 2002·Circulation·Hiroshi YabushitaGuillermo J Tearney
Apr 25, 2006·Journal of the American College of Cardiology·Jay D CaplanJames E Muller
May 6, 2006·Journal of Biomedical Optics·Guillermo J TearneyBrett E Bouma
Jul 11, 2006·Nature Biotechnology·Hao F ZhangLihong V Wang
Nov 23, 2006·Nature Medicine·Seok H YunBrett E Bouma
Feb 22, 2008·Nature·Javier Sanz, Zahi A Fayad
Jun 11, 2008·Optics Express·Shriram SethuramanStanislav Y Emelianov
Nov 1, 2008·Journal of Interventional Cardiology·Sergio Waxman
Aug 12, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Faisal Sharif, Ross T Murphy
Dec 25, 2009·Circulation. Cardiovascular Interventions·Akiko MaeharaNeil J Weissman
Feb 2, 2010·The Review of Scientific Instruments·Andrei B KarpioukStanislav Y Emelianov
Sep 3, 2010·Optics Letters·Bao-Yu HsiehPai-Chi Li
Mar 4, 2011·Optics Letters·Krista JansenGijs van Soest
Mar 31, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Kim DoumaMarc A M J van Zandvoort
Jul 2, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Daniel RazanskyVasilis Ntziachristos
Aug 7, 2012·Interface Focus·Paul Beard
Jan 1, 1999·Journal of Biomedical Optics·A RogganG Mu Ller

❮ Previous
Next ❯


Dec 12, 2012·Journal of Biomedical Optics·Doug YeagerStanislav Emelianov
Oct 23, 2012·Journal of Biomedical Optics·Andrei B KarpioukStanislav Y Emelianov
Jan 7, 2014·Medical Physics·Christian LutzweilerDaniel Razansky
Oct 11, 2014·Photoacoustics·Krista JansenGijs van Soest
Dec 2, 2015·ACS Nano·Min Young LeeSei Kwang Hahn
Jan 15, 2014·Ultrasound in Medicine & Biology·Jami L JohnsonMichelle Sabick
Mar 19, 2014·Ultrasound in Medicine & Biology·Krista JansenAntonius F W van der Steen
May 18, 2016·Ultrasound in Medicine & Biology·Verya DaeichinGijs van Soest
Sep 28, 2016·Ultrasonography·Keerthi S Valluru, Juergen K Willmann
Aug 31, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Saugata SinhaVikram S Dogra
Jun 9, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Saugata SinhaNavalgund A Rao
Mar 9, 2017·Biomedical Optics Express·Gurneet S SanghaCraig J Goergen
Mar 23, 2019·Biomaterials Science·Mirko MaturiMauro Comes Franchini
Oct 12, 2019·Cardiovascular Intervention and Therapeutics·Kenichi FujiiTakashi Akasaka
Jan 24, 2018·Biomedical Optics Express·Takashi BumaSang Won Choi
Aug 29, 2014·Optics Letters·Pengfei HaiLihong V Wang
Mar 18, 2015·Biomedical Optics Express·Pavel SubochevIlya Turchin
Mar 5, 2014·Journal of Biomedical Optics·Bin RaoLihong V Wang
Nov 30, 2016·Biomedical Optics Express·Robin F CastelinoF Stuart Foster
Mar 21, 2019·Biomedical Optics Express·Brittani BungartJi-Xin Cheng
Dec 20, 2019·Tissue Engineering. Part B, Reviews·Binita ShresthaEric M Brey
Jul 1, 2016·Physics Education·D I NikitichevT Vercauteren
Apr 17, 2019·Nature Biomedical Engineering·Murad OmarVasilis Ntziachristos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Imaging in CNS

Here is the latest research on cell imaging and imaging modalities, including light-sheet microscopy, in the central nervous system.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.