Spectroscopic spectral-domain optical coherence microscopy

Optics Letters
Chengyang XuStephen A Boppart

Abstract

The spectroscopic content within optical coherence tomography (OCT) data can provide a wealth of information. Spectroscopic OCT methods are frequently limited by time-frequency trade-offs that limit high spectral and spatial resolution simultaneously. We present spectroscopic spectral-domain optical coherence microscopy performed with a multimodality microscope. Restricting the spatial extent of the signal by using high-numerical-aperture optics makes high-resolution spectroscopic information accessible, facilitated with spectral-domain detection. Simultaneous acquisition of multiphoton microscopy images is used to validate tissue structure and localization of nuclei within individual cells.

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Citations

Apr 4, 2008·International Journal of Biomedical Imaging·L FroehlyV Couderc
Nov 13, 2007·Journal of Biomedical Optics·Adam M ZyskStephen A Boppart
Nov 22, 2008·Journal of Biomedical Optics·Robin G ChelliyilStephen A Boppart
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