Spectroscopic Studies of Fluorescence Effects in Bioactive 4-(5-Heptyl-1,3,4-Thiadiazol-2-yl)Benzene-1,3-Diol and 4-(5-Methyl-1,3,4-Thiadiazol-2-yl)Benzene-1,3-Diol Molecules Induced by pH Changes in Aqueous Solutions

Journal of Fluorescence
Arkadiusz MatwijczukMariusz Gagoś

Abstract

This paper presents the results of stationary fluorescence spectroscopy and time-resolved spectroscopy analyses of two 1,3,4-thiadiazole analogues, i.e. 4-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (C1) and 4-(5-heptyl-1,3,4-thiadiazol-2-yl)benzene-1,3-diol (C7) in an aqueous medium containing different concentrations of hydrogen ions. An interesting dual florescence effect was observed when both compounds were dissolved in aqueous solutions at pH below 7 for C1 and 7.5 for C7. In turn, for C1 and C7 dissolved in water at pH higher than the physiological value (mentioned above), single fluorescence was only noted. Based on previous results of investigations of the selected 1,3,4-thiadiazole compounds, it was noted that the presented effects were associated with both conformational changes in the analysed molecules and charge transfer (CT) effects, which were influenced by the aggregation factor. However, in the case of C1 and C7, the dual fluorescence effects were visible in a higher energetic region (different than that observed in the 1,3,4-thiadiazoles studied previously). Measurements of the fluorescence lifetimes in a medium characterised by different concentrations of hydrogen ions revealed clear lengthening of the ...Continue Reading

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Citations

Jun 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shailee V TiwariAnna Pratima G Nikalje
Apr 30, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology· IlaG Krishnamoorthy
Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fawzia F AlblewiAhmed M El-Agrody
Jun 5, 2020·Journal of Fluorescence·Shivaprasadagouda PatilAshok H Sidarai
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Grzegorz CzernelArkadiusz Matwijczuk
Apr 16, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Reshmi Dani IlaG Krishnamoorthy

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Methods Mentioned

BETA
fluorescence
Fluorescence Spectroscopy
light scattering

Software Mentioned

AI
Grams
DAS6
DataStation

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