PMID: 2490102Jan 1, 1989Paper

Spectroscopic study of the interaction of coumarin anticoagulant drugs with polyvinylpyrrolidone

Journal of Pharmaceutical and Biomedical Analysis
M OtagiriU Matsumoto

Abstract

The interaction of coumarin anticoagulants with polyvinylpyrrolidone (PVP) was investigated using a fluorescence technique. The fluorescence intensities of warfarin and phenprocoumon were greatly enhanced following binding to PVP, while the fluorescence of 4-hydroxycoumarin was little enhanced in the presence of PVP. The enhanced fluorescence of warfarin and phenprocoumon bound to PVP can be explained by their incorporation into the hydrophobic environment in the PVP and by a decrease in the internal rotation of the alpha-substituted benzyl group in the drugs. The binding parameters of warfarin and phenprocoumon were estimated by the Klotz method; the binding constants for phenprocoumon and warfarin were found to be 2.6 X 10(4) and 2.2 X 10(4) M-1, respectively. The 13C-NMR measurements suggest the lactone moiety in the 4-hydroxycoumarin and the substituted benzene ring play an important role in the binding to PVP.

References

Aug 1, 1977·Journal of Pharmaceutical Sciences·C H HsiaoM I Blake
Jun 1, 1987·The Journal of Pharmacy and Pharmacology·M OtagiriY Imamura
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D D GianniniJ D Roberts
May 1, 1971·Journal of Pharmaceutical Sciences·M J ChoM Pernarowski
Mar 11, 1968·Archives of Biochemistry and Biophysics·I M Klotz, K Shikama
Jul 1, 1980·The Journal of Pharmacy and Pharmacology·M OtagiriJ H Perrin
Dec 1, 1980·Journal of Pharmaceutical Sciences·J A Plaizier-Vercammen, R E De Nève

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Citations

Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·R J MumperA P Rolland
Apr 19, 2012·Colloids and Surfaces. B, Biointerfaces·Zhaoqiang WuHong Chen
Jul 9, 2020·Nanoscale·Nicholas AndrikopoulosPu Chun Ke
Mar 18, 2021·The Journal of Physical Chemistry. B·Sushil S SakpalSayan Bagchi

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