Spectrum of 2,836 cases of invasive bacterial or fungal infections in children: results of prospective nationwide five-year surveillance in Finland. Finnish Pediatric Invasive Infection Study Group

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M SaarinenJ Eskola

Abstract

In a prospective nationwide laboratory-based surveillance study of all invasive bacterial and fungal infections among children < 16 years of age, 2,836 clinical cases were registered during the 5-year period 1985-1989. Of these cases, 136 were polymicrobial. During the study period, nationwide administration of Haemophilus influenzae type b conjugate vaccine reduced the incidence rates of invasive infection caused by this organism. The most common clinical diagnosis (48% of cases) was bacteremia without an identified focus of infection. The age-specific annual incidence rates of all invasive infections in children < or = 15 years of age, in children < or = 4 years of age, in children < or = 1 year of age, and in children < or = 28 days of age were 55.8, 141.4, 272.7, and 2,749.0 cases/100,000 person-years, respectively. Thirty percent of the children in the study had an underlying condition predisposing to infection. The case-fatality rate was 4.1% for all cases of invasive infection.

Citations

Sep 24, 1999·The Pediatric Infectious Disease Journal·S KalliolaJ Eskola
May 1, 2007·The Pediatric Infectious Disease Journal·Marianne Sjølin FrederiksenThomas Benfield
Apr 10, 2008·The Pediatric Infectious Disease Journal·Deena SutterJudith Epstein
May 14, 2004·Clinical Pharmacokinetics·Matthijs de HoogJohn N van den Anker
Jul 20, 2010·Tropical Medicine & International Health : TM & IH·Aatekah OwaisAnita K M Zaidi
Nov 6, 2012·Acta Paediatrica·Joachim LuthanderMargareta Eriksson
Jan 15, 1999·Critical Reviews in Microbiology·C M Kahler, D S Stephens

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