Spectrum of corrosive esophageal injury after intentional paraquat ingestion

The American Journal of Emergency Medicine
Tzung-Hai YenYu-Hui Chen

Abstract

This is an observational study that examines the clinical features, the degrees of esophageal injury, physiological markers, and clinical outcomes after paraquat ingestion and seeks to determine what association, if any, may exist between these findings. The study included 16 of 1410 paraquat subjects who underwent endoscopies at Chang Gung Memorial Hospital between 1980 and 2007. Corrosive esophageal injuries were classified as grade 1 in 8, 2a in 5, and 2b in 3 patients. No patients had grade 0, 3a, or 3b esophageal injuries. After paraquat ingestion, systemic toxicity occurred, with rapid development of hypoxia, hepatitis, and renal failure in many cases. Hypoxia occurred in 1 (12.5%), 5 (100%), and 3 (100%) patients with grades 1, 2a, and 2b esophageal injury, respectively. There were more hypoxic patients with grades 2a and 2b than those with grade 1 esophageal injury (P < .05). The nadir Pao(2) was lower in patients with grades 2a and 2b than those with grade 1 esophageal injury (P < .05). However, there were no significant differences in terms of acute hepatitis, peak serum alanine aminotransferase, acute renal failure, and peak serum creatinine between the 3 groups (P > .05). Kaplan-Meier analysis did not find any diffe...Continue Reading

References

May 13, 1978·British Medical Journal·P AckrillA J Ralston
Mar 1, 1992·Human & Experimental Toxicology·J H PerriënsH Chee
Mar 1, 1992·Gastrointestinal Endoscopy·F ValianteR Naccarato
Jul 1, 1988·Human Toxicology·A R Talbot, M R Barnes
Sep 5, 1987·British Dental Journal·R S Dobson, A C Smith
Jan 1, 1987·Human Toxicology·J A ValeB M Buckley
Jan 1, 1987·Human Toxicology·J M ScherrmannR Bourdon
Jul 1, 1970·The Biochemical Journal·A D Dodge, N Harris
Nov 1, 1995·Archives of Environmental Health·J L LinM L Leu
Nov 1, 2008·International Journal of Epidemiology·Yvonne KellyMaria A Quigley

❮ Previous
Next ❯

Citations

Mar 27, 2013·Pediatric Emergency Care·Yi-Wen HsiehTzung-Hai Yen
Jun 8, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Chin-Jung YangTzung-Hai Yen
Jan 7, 2014·Scientific Reports·Shiguo SunXiaojun Peng
Oct 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Blazena CaganovaMagdalena Kuzelova
Mar 9, 2011·Human & Experimental Toxicology·Ting-Yi SuTzung-Hai Yen
Mar 30, 2017·Experimental and Therapeutic Medicine·Xiaoyan XuYunbei Yu
Apr 1, 2020·The Journal of International Medical Research·Changbao HuangXigang Zhang
Jun 20, 2014·Experimental and Therapeutic Medicine·Guangcai YuChengzhen Song
Oct 29, 2020·Physical Chemistry Chemical Physics : PCCP·Sharmistha Dutta Choudhury, Haridas Pal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.