Spectrum of Microbial Diseases and Resistance Patterns at a Private Teaching Hospital in Kenya: Implications for Clinical Practice

PloS One
Daniel MainaRodney D Adam

Abstract

Accurate local prevalence of microbial diseases and microbial resistance data are vital for optimal treatment of patients. However, there are few reports of these data from developing countries, especially from sub-Saharan Africa. The status of Aga Khan University Hospital Nairobi as an internationally accredited hospital and a laboratory with an electronic medical record system has made it possible to analyze local prevalence and antimicrobial susceptibility data and compare it with other published data. We have analyzed the spectrum of microbial agents and resistance patterns seen at a 300 bed tertiary private teaching hospital in Kenya using microbial identity and susceptibility data captured in hospital and laboratory electronic records between 2010 and 2014. For blood isolates, we used culture collection within the first three days of hospitalization as a surrogate for community onset, and within that group, Escherichia coli was the most common, followed by Staphylococcus aureus. In contrast, Candida spp. and Klebsiella pneumoniae were the most common hospital onset causes of bloodstream infection. Antimicrobial resistance rates for the most commonly isolated Gram negative organisms was higher than many recent reports from...Continue Reading

References

Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Jun 28, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·O LyytikäinenUNKNOWN Hospital Infection Surveillance Team
Mar 11, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara A MirzaRana A Hajjeh
Apr 20, 2004·AIDS·Françoise DromerUNKNOWN French Cryptococcosis Study Group
Aug 20, 2004·QJM : Monthly Journal of the Association of Physicians·J A EvansE Frimpong
Jan 7, 2005·The New England Journal of Medicine·James A BerkleyJ Anthony G Scott
Oct 25, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Alicia I HidronUNKNOWN Participating National Healthcare Safety Network Facilities
Nov 4, 2008·The Lancet Infectious Diseases·Tim PlancheSanjeev Krishna
Jun 1, 2010·The Lancet Infectious Diseases·Elizabeth A ReddyJohn A Crump
Aug 31, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Godfrey BigogoDaniel R Feikin
Dec 1, 2010·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Apr 27, 2011·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Mar 1, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Gonçalves-PereiraA H Carneiro
Dec 12, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dawn M SievertUNKNOWN National Healthcare Safety Network (NHSN) Team and Participating NHSN Facilities
Nov 13, 2013·Pediatrics·Eric BiondiFrancis Gigliotti
Nov 21, 2013·The Lancet Infectious Diseases·Ramanan LaxminarayanOtto Cars
Jan 8, 2014·Clinical Microbiology Reviews·Kari A SimonsenH Dele Davies
Jun 1, 2014·The Journal of Antimicrobial Chemotherapy·Stije J LeopoldConstance Schultsz
Apr 19, 2015·BMC Research Notes·Kevin B LauplandDeirdre L Church
Jun 4, 2015·JAMA : the Journal of the American Medical Association·Tracy Hampton

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Citations

Dec 21, 2017·Emerging Infectious Diseases·Henry KajumbulaYukari C Manabe
Dec 14, 2018·The Journal of Antimicrobial Chemotherapy·Elizabeth A AshleySharon J Peacock
Mar 5, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ngure KagiaSusan C Morpeth
Jul 11, 2019·BMC Infectious Diseases·Frederick K WangaiR Andrew Seaton
Sep 1, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·David NestorMartin Sundqvist
Feb 26, 2021·Journal of Clinical Pharmacy and Therapeutics·Suraj ShresthaShyam Kumar Mishra

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