PMID: 69792Jul 23, 1977Paper

Spectrum of thyroid function in patient's remaining in remission after antithyroid drug therapy for thyrotoxicosis

Lancet
W J IrvineE H Cameron

Abstract

Thyroid function was assessed in 110 patients who were in remission for a period of 7-6 +/- 0-6 years (mean +/- S.E.) (range 0-25--25 years) after the withdrawal of antithyroid drug therapy for thyrotoxicosis. On the basis of clinical examination and on the results of thyroid-function tests, the following group of patients were identified: (I) euthyroid with normal plasma-total thyroxine (T4) and triiodothyronine (T3) concentrations, but an absent or subnormal response of plasma-thyrotrophin (T.S.H.) to thyrotrophin-releasing hormone (T.R.H.) (16%); (II) euthyroid with normal concentrations of plasma total T4 and T3 and a normal plasma-T.S.H. response to T.R.H. (59%); (III) euthyroid with normal concentrations of circulating thyroid hormones and a normal basal plasma-T.S.H., but an exaggerated plasma-T.S.H. response to T.R.H. (13%); (IV) euthyroid with normal plasma total T4 and T3 concentrations, but a raised basal plasma-T.S.H. concentration and an exaggerated plasma-T.S.H. response to T.R.H. (6%); (V) hypothyroid (6%). Although the need for short-term follow-up to identify those patients treated with antithyroid drugs who will relapse is well recognised, 16% of all patients in remission for longer than 4 years (10-8 +/- 0-7 ...Continue Reading

Citations

Jun 14, 1986·Lancet·G HennemannK Sankaranarayanan
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P J Leslie, A D Toft
Apr 9, 1998·Baillière's Clinical Endocrinology and Metabolism·A Toft
Mar 23, 1978·The New England Journal of Medicine·R Utiger
Aug 16, 1984·The New England Journal of Medicine·V SridamaL J DeGroot
Sep 1, 1991·Clinical Endocrinology·J J Farrar, A D Toft
Mar 5, 1983·British Medical Journal·A D Toft
Aug 1, 1985·Postgraduate Medical Journal·N R SteelP Kendall-Taylor
Oct 1, 1981·Journal of Endocrinological Investigation·B A LambergT Mäkinen
Jan 1, 1980·Metabolism: Clinical and Experimental·A KiddR Volpé
Jul 28, 2009·Journal of the American College of Surgeons·Haejin InJennifer E Rosen
Jun 1, 1997·Thyroid : Official Journal of the American Thyroid Association·P VittiA Pinchera
Jun 30, 2006·International Journal of Clinical Practice·D J CuthbertsonG P Leese
Jun 12, 2004·The Kaohsiung Journal of Medical Sciences·Yueh-Hua ChungTa-Jen Wu
Mar 1, 1980·Acta paediatrica Scandinavica·J Mäenpää, A Kuusi
Jan 1, 1982·Acta Medica Scandinavica·L E Holm, I Alinder
Nov 1, 1985·Journal of the Royal Society of Medicine·P J HoskinC L Harmer
Nov 15, 2006·Southern Medical Journal·Adriana V C De MoraesJoão H Romaldini
Oct 1, 1978·Scottish Medical Journal·A D Toft
Mar 27, 2019·Endocrinology and Metabolism·Wilmar M Wiersinga
Jul 1, 1982·Scottish Medical Journal·A D ToftJ Seth
Nov 22, 1984·The New England Journal of Medicine·D S Cooper

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