Speculations on the evolution of the genetic code. II

Origins of Life
H Hartman


An evolutionary scheme is postulated in which a primitive code, involving only guanine and cytosine, would code for glycine (GG), alanine (GC), arginine (CG) and proline (CC). From each of these amino acids and their codons, there evolves a family of related amino acids as the code expands. The four families are: (1) alanine valine, leucine, isoleucine, phenylalanine, tyrosine, methionine and tryptophane; (2) proline, threonine and serine; (3) arginine, lysine, and histidine; (4) glycine, serine cysteine, glutamic acid, glutamine, aspartic acid and asparagine. Except for the glycine relation to glutamic acid and aspartic acid, all amino acids are related by chemical similarities in their side chains. Glycine not having a side chain would permit a more complex set of substitutions.


Jul 1, 1975·Origins of Life·H Hartman
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D M CrothersG Söll
Dec 1, 1968·Journal of Molecular Biology·F H Crick


Mar 1, 1982·Origins of Life·R R Kocherlakota, N D Acland
Dec 1, 1982·Origins of Life·C C King
Sep 1, 1980·Origins of Life·M Hasegawa, T Miyata
Oct 9, 2007·Journal of Molecular Evolution·Gregory P Fournier, J Peter Gogarten
Jun 6, 2002·Trends in Genetics : TIG·Michael Syvanen
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Rodin, S Ohno
Jun 1, 1995·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·H Hartman

Related Concepts

Arginine hydrochloride
Biological Evolution
Genetic Code
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