PMID: 7022271Jan 1, 1981Paper

Speculations on the mechanism of action of hallucinogenic indolealkylamines

Neuroscience and Biobehavioral Reviews
R A Glennon, J A Rosecrans

Abstract

In this review we attempt to develop a fluid theoretical model which is being used as a strategy-base for future experimentation. The first two sections (A and B) describe how we have conducted our research, and present the perspective value of each. This is important because the research strategies developed in these laboratories over the last 5 years combine in vitro and in vivo pharmacological techniques as a means of understanding mechanisms of drug action. Sections C and D attempt to describe how we interpret our data and how we have utilized these data to formulate hypotheses concerning drug mechanisms. The last section of this review sets forth our own ideas on how we believe hallucinogenic agents produce their effects and presents some original data, which we feel, allows us to develop the overall hypotheses presented.

References

Jun 1, 1976·The Journal of Pharmacy and Pharmacology·J L Bennett, G K Aghajanian
Apr 1, 1979·Journal of Medicinal Chemistry·R A Glennon, P K Gessner
Apr 16, 1979·Life Sciences·R A Glennon
Dec 1, 1979·Neuropharmacology·J A Rosecrans, R A Glennon
Nov 1, 1979·Journal of Medicinal Chemistry·R A GlennonB J Kline
Mar 1, 1977·Pharmazie in unserer Zeit·H E Geissler, E Mutschler
Jul 1, 1975·Pharmacology, Biochemistry, and Behavior·M A GeyerA J Mandell
May 1, 1974·European Journal of Pharmacology·A L Frankhuijzen, I L Bonta
Mar 1, 1968·European Journal of Pharmacology·P F Sonneville
Mar 1, 1980·Journal of Medicinal Chemistry·R A GlennonG M Anderson
Sep 1, 1980·Journal of Medicinal Chemistry·R A GlennonJ A Rosecrans
Jan 7, 1978·Journal of Allied Health·R H Boatman
Mar 14, 1957·Annals of the New York Academy of Sciences·J H GADDUM
Mar 14, 1957·Annals of the New York Academy of Sciences·E ROTHLIN
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·J R VANE
Jun 1, 1959·British Journal of Pharmacology and Chemotherapy·R B BARLOW, I KHAN
Jan 1, 1967·British Journal of Pharmacology and Chemotherapy·R E Handschumacher, J R Vane

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Citations

Jan 1, 1982·Psychopharmacology·F J White, J B Appel
Aug 19, 1983·European Journal of Pharmacology·M Emmett-OglesbyH Lal
Nov 2, 1993·European Journal of Pharmacology·M D Schechter, T L Gordon
Dec 1, 1983·Neuropharmacology·H Lal, M W Emmett-Oglesby
Jan 1, 1983·Neuropharmacology·M W Emmett-OglesbyH Lal
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·M D Schechter, D M Lovano
Dec 1, 1985·Pharmacology, Biochemistry, and Behavior·R A Glennon, A E Hauck
Jun 1, 1985·Pharmacology, Biochemistry, and Behavior·M D Schechter, R A Glennon
Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·M D SchechterJ W Boja
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·D M Wood, M W Emmett-Oglesby
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·M D SchechterD J Calcagnetti
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·R A Glennon, J A Rosecrans
Jan 1, 1990·Pharmacology & Therapeutics·P Kalix
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·D X Freedman
Jul 1, 1992·Annals of the New York Academy of Sciences·P A TuetingN N Boutros

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