Speech structure links the neural and socio-behavioural correlates of psychotic disorders.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Lena PalaniyappanPeter F Liddle

Abstract

A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization. Using structural and functional imaging, we investigated the neural basis and the functional relevance of the structural connectedness of speech samples obtained from 56 patients with psychosis (22 with bipolar disorder, 34 with schizophrenia). Speech structure was assessed by non-semantic graph analysis. We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing speed deficits) and iv) functional outcome in patients. Of various clinical metrics, only speech connectedne...Continue Reading

Citations

Feb 13, 2020·Current Opinion in Psychiatry·Janna N de BoerIris E C Sommer
Jun 28, 2020·Human Brain Mapping·Xiaowei ZhuangDietmar Cordes
Aug 12, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·S S HaasC M Corcoran
Jun 11, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Geraldo Busatto FilhoFabio L Duran
Dec 12, 2018·NPJ Schizophrenia·Natália Bezerra MotaSidarta Ribeiro
Apr 23, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Felipe ArgoloRodrigo A Bressan
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Jun 15, 2021·Journal of Alzheimer's Disease : JAD·Bárbara Luzia Covatti MalcorraLilian Cristine Hübner
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Sep 12, 2021·Seminars in Cell & Developmental Biology·Lena Palaniyappan
Nov 24, 2021·Scandinavian Journal of Psychology·Ido ZivNachum Dershowitz

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