Speeding up the evaluation of new agents in cancer.

Journal of the National Cancer Institute
Mahesh Kb ParmarPatrick Royston

Abstract

Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.

Associated Clinical Trials

References

Mar 15, 1994·Statistics in Medicine·R SimonS S Ellenberg
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S O'ReillyE K Rowinsky
May 29, 1997·The New England Journal of Medicine·J C Bailar, H L Gornik
Jun 2, 1998·Lancet·D Lane
Feb 28, 2003·Journal of Health Economics·Joseph A DiMasiHenry G Grabowski
May 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masahiro FukuokaJosé Baselga
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas G RobertsBruce A Chabner
Feb 12, 2004·The Lancet Infectious Diseases·Penelope A BryantNigel Curtis
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstDavid H Johnson
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Sep 16, 2006·Biometrical Journal. Biometrische Zeitschrift·Heinz SchmidliWilli Maurer
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy

❮ Previous
Next ❯

Citations

Dec 24, 2013·Current Opinion in Pediatrics·Pamela Kearns, Bruce Morland
Feb 6, 2013·Nature Reviews. Rheumatology·Maya H BuchPaul Emery
Sep 4, 2009·Nature Reviews. Urology·Gerhardt Attard, Johann S de Bono
Mar 27, 2012·The Journal of Infectious Diseases·Patrick P J PhillipsMichael Hoelscher
Dec 13, 2012·Journal of the National Cancer Institute·Yaacov Richard LawrenceAdam P Dicker
Feb 22, 2012·Clinical Obstetrics and Gynecology·Michael A Bookman
Oct 1, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally HunsbergerRichard Simon
Nov 16, 2013·BMC Medical Research Methodology·Daniel J BrattonMahesh K B Parmar
Mar 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hui TangDaniel J Sargent
Jan 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward L KornSusan Halabi
Mar 6, 2012·Clinical Investigation·Sumithra J Mandrekar, Daniel J Sargent
Nov 19, 2013·Gynecologic Oncology·Thomas J HerzogRonald D Alvarez
Mar 15, 2014·Journal of the National Cancer Institute·Michael A BookmanKenneth D Swenerton
Jul 2, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Janakiraman SubramanianRamaswamy Govindan
Oct 18, 2011·Contemporary Clinical Trials·Martha Fors LópezCarmen Viada Gonzalez
Sep 29, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jonathan A Ledermann, Fharat A Raja
Feb 23, 2010·Seminars in Oncology·Richard J Epstein
Jan 15, 2014·Statistics in Medicine·James M S Wason, Lorenzo Trippa
Apr 24, 2014·Statistics in Medicine·Michael A Proschan, Lori E Dodd
Feb 2, 2015·The Lancet Oncology·Michelle K WilsonAmit M Oza
Sep 2, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·N D JamesM K B Parmar
Dec 30, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jan BogaertsMatthew Seymour
Jul 19, 2011·Contemporary Clinical Trials·C L JonesL Kaiser
Jul 8, 2011·Blood·Robert K Hills, Alan K Burnett
Nov 24, 2012·The Journal of Infectious Diseases·Patrick P J PhillipsMichael Hoelscher
Nov 3, 2016·Statistics in Medicine·Thomas Jaki, Despina Vasileiou
Nov 20, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard KaplanMahesh Parmar
Mar 17, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm D MasonUNKNOWN STAMPEDE Investigators
Dec 10, 2014·Current Opinion in Obstetrics & Gynecology·Isabelle Ray-CoquardJonathan A Ledermann
Dec 18, 2012·Statistical Methods in Medical Research·James WasonThomas Jaki
Oct 2, 2015·Statistical Methods in Medical Research·Christian Holm HansenChristopher J Weir
Jul 12, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Deborah FordDiana M Gibb
Feb 26, 2016·PloS One·Miranta AntoniouRuwanthi Kolamunnage-Dona
Jan 17, 2019·Clinical Trials : Journal of the Society for Clinical Trials·Alexandra BlenkinsopBabak Choodari-Oskooei
Oct 19, 2017·Nature Reviews. Clinical Oncology·Min Yuen TeoHoward I Scher

❮ Previous
Next ❯

Software Mentioned

STAMPEDE
Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.