PMID: 9160413Aug 1, 1996Paper

Speeds of action of single doses of formoterol and salbutamol compared with placebo in reversing methacholine-induced bronchoconstriction

Pulmonary Pharmacology
J R BeachD J Hendrick

Abstract

We compared the speeds of action of two doses of the long acting beta-agonist formoterol (12 micrograms and 24 micrograms) with those of salbutamol (400 micrograms) and placebo using a double-blind, randomized, cross-over study design in 16 asthmatic subjects. A methacholine test was used on four separate study days to produce a standardized degree of bronchoconstriction (a decrement in FEV1 > or = 20%) and one of the study medications as dry powder was administered immediately afterwards via an Aerolizer inhaler device. The speeds of recovery were estimated from measurements of FEV1 over the following 2-90 min. All active treatments produced significantly greater bronchodilation than placebo as early as 2 min after administration, and their peak effects within 10 min; and no significant differences were noted between them. Mean recovery times by 50% of the FEV1 decrement provoked by methacholine were significantly shorter for the active medications: 5.7 min (formoterol 24 micrograms), 6.4 min (salbutamol 400 micrograms), 10.2 min (formoterol 12 micrograms), and 53.1 min (placebo); the respective times for recovery by 80% being 18.0, 17.4, 22.1, and 83.3 min. We conclude that single doses of the dry powder formulations of all t...Continue Reading

Citations

Oct 13, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Peter HaidlDieter Koehler
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Hanneke J van der Woude, René Aalbers
Nov 10, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S DelpierreM Badier
Jul 27, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ann WatsonNeil Pride
Nov 13, 2004·Current Medical Research and Opinion·Jan Lötvall

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