spenito is required for sex determination in Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America
Dong Yan, N Perrimon

Abstract

Sex-lethal (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by controlling sex identity in both soma and germ line. In females Sxl maintains its own expression by controlling the alternative splicing of its own mRNA. Here, we identify a novel sex determination gene, spenito (nito) that encodes a SPEN family protein. Loss of nito activity results in stem cell tumors in the female germ line as well as female-to-male somatic transformations. We show that Nito is a ubiquitous nuclear protein that controls the alternative splicing of the Sxl mRNA by interacting with Sxl protein and pre-mRNA, suggesting that it is directly involved in Sxl auto-regulation. Given that SPEN family proteins are frequently mutated in cancers, our results suggest that these factors might be implicated in tumorigenesis through splicing regulation.

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Citations

Jan 28, 2016·Seminars in Cell & Developmental Biology·Benoit Moindrot, Neil Brockdorff
Jul 5, 2017·Nature Communications·Lijuan KanEric C Lai
Jun 24, 2017·PLoS Genetics·Kelsey E HazeghTânia Reis
Aug 22, 2018·Fly·Annick Sawala, Alex P Gould
Sep 27, 2018·Wiley Interdisciplinary Reviews. RNA·Hong-Chao DuanGuifang Jia
Nov 20, 2018·PLoS Genetics·Maheva AndriatsilavoAllison J Bardin
Mar 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Magdalena WoloszynskaMieke Van Lijsebettens
Mar 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jian GuoDong Yan
Jul 21, 2020·Wiley Interdisciplinary Reviews. RNA·David Garcias Morales, José L Reyes
Oct 5, 2017·PLoS Biology·Annick Sawala, Alex P Gould
Apr 14, 2021·Nature Communications·Yanhua WangDong Yan
Aug 14, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Daniel G CalameJames R Lupski
Dec 18, 2018·Biochemistry·Dario L Balacco, Matthias Soller

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