Sperm and Seminal Plasma Proteomics: Molecular Changes Associated with Varicocele-Mediated Male Infertility

The World Journal of Men's Health
Manesh Kumar Panner Selvam, Ashok Agarwal

Abstract

Male infertility is a rising problem and the etiology at the molecular level is unclear. Use of omics has provided an insight into the underlying cellular changes in the spermatozoa of infertile men. Proteomics is one the promising omics techniques for biomarker screening that can provide complete information on molecular processes associated with male infertility. Varicocele is a pressing issue in the field of male infertility and the search for an appropriate diagnostic and therapeutic biomarker is still ongoing. In this review, we discuss the reports on proteomic profiles of sperm and seminal plasma in male infertility and provide an in-depth insight into varicocele studies associated with male infertility.

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Citations

Sep 30, 2020·International Journal of Molecular Sciences·Luz Candenas, Rosanna Chianese
Jul 3, 2021·International Journal of Environmental Research and Public Health·Kamil GillMalgorzata Piasecka
Nov 24, 2021·Expert Review of Proteomics·Sophia Costa Araujo, Ricardo Pimenta Bertolla

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Methods Mentioned

BETA
electrophoresis
protein
acetylation
ELISA

Software Mentioned

Reactome
STRING ( Search Tool for the Retrieval of Interacting Genes Pr...
IPA
Metacore
Cytoscape
Ingenuity Pathway Analysis ( IPA )

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