Sperm axoneme: a tale of tubulin posttranslation diversity

Molecular Reproduction and Development
Abraham L Kierszenbaum

Abstract

Two microtubule-containing structures are assembled during spermiogenesis: a transient manchette and a stable axoneme. Both structures contain microtubules enriched in posttranslationally modified tubulins. Despite the existence of a spectrum of tubulin isotypes postulated by the multi-tubulin hypothesis, further extended by an elaborated array of posttranslational modifications, it is unknown how this diversity influences microtubule function. There is increasing evidence that different alpha beta-tubulin isotypes can affect the structure and function of microtubules. It is also becoming increasingly clear that eukaryotic cells encode other tubulin proteins expressed by the tubulin superfamily: gamma, delta epsilon, zeta eta, and FtsZ have been identified so far. Although the role of gamma-tubulin in the nucleation of microtubule assembly is well established, the function of delta-, epsilon-, zeta-, eta-, and FtsZ-tubulins is less understood. The members of the tubulin superfamilies found in spermatids include the alpha beta-tubulin dimer, in addition to gamma-tubulin in the centrosome, and delta-tubulin in the perinuclear ring region of the mouse spermatid manchette, the centrosome region, and flagellum. Posttranslational mod...Continue Reading

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Citations

Aug 24, 2013·General and Comparative Endocrinology·Ksenia J GrohMarc J-F Suter
Nov 26, 2003·General and Comparative Endocrinology·Gilda CobellisSilvia Fasano
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Aug 3, 2021·Frontiers in Cell and Developmental Biology·Mari-Carmen Fuentes-AlberoFrancisco Alberto García-Vázquez

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