Sperm contributions to oocyte activation: more that meets the eye

Journal of Assisted Reproduction and Genetics
George AnifandisIoannis E Messinis

Abstract

It is well known that for successful fertilization, oocyte activation is required, which involves a signal transduction cascade leading to the conversion of the oocyte to a diploid embryo. During oocyte activation, intracellular calcium levels oscillate repetitively causing exocytosis of cortical granules, the enzymes which the latter contain are released into the perivitelline space, leading to modifications of the zona pellucida (ZP), which prevent the penetration of the ZP by further spermatozoa. The necessary element that initiates oocyte activation is apparently the release of intracellular calcium (Ca(2+)) stored in the endoplasmic reticulum (ER). The exact mechanism via which Ca(2+) is released within the oocyte has not been yet clarified, and has been a matter of an ongoing debate. Today, the sperm factor hypothesis has gained general acceptance, according to which a sperm molecule, either phospholipase C (PLCζ) or a post-acrosomal sheath WW domain-binding protein (PAWP), diffuses into the ooplasm initiating a molecular cascade involving mainly the phosphoinositide pathway. Mounting evidence now indicates that these calcium oscillations are caused by a testis-specific PLC termed PLCζ, released into the oocyte following ...Continue Reading

References

Jun 27, 2006·Journal of Pharmacological Sciences·Shunichi Miyazaki, Masahiko Ito
Oct 30, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Sook-Young Yoon, Rafael A Fissore
Nov 22, 2007·Developmental Biology·Manabu KurokawaRafael A Fissore
Aug 9, 2011·Molecular Reproduction and Development·Junya ItoRafael A Fissore
Nov 17, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michail NomikosF Anthony Lai
Aug 1, 2013·Molecular Reproduction and Development·Junaid KashirStephen A Stricker
Jun 4, 2014·Reproduction in Domestic Animals = Zuchthygiene·E DovolouG S Amiridis
Jun 28, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mahmoud AarabiRichard Oko
Jul 15, 2015·Biology of Reproduction·Siti Nornadhirah AmdaniKevin Coward
Sep 9, 2015·Human Reproduction Update·Marc YesteKevin Coward
Oct 11, 2015·Cell and Tissue Research·Zoltan Machaty

❮ Previous
Next ❯

Citations

Apr 10, 2016·Journal of Assisted Reproduction and Genetics·Debora A AnzalonePasqualino Loi
Sep 9, 2016·Cellular and Molecular Life Sciences : CMLS·Jacinta H MartinBrett Nixon
Sep 11, 2016·Journal of Assisted Reproduction and Genetics·Elham Janghorban-LarichehMohammad H Nasr-Esfahani
Sep 13, 2018·Systems Biology in Reproductive Medicine·George AnifandisDimitrios G Goulis
May 16, 2017·Journal of Morphology·Amin GolpourHamid Niksirat
Nov 23, 2016·The Journal of Endocrinology·Shuai Li, Wipawee Winuthayanon
Mar 11, 2017·The Journal of Membrane Biology·Soudabeh Sabetian, Mohd Shahir Shamsir
Feb 13, 2021·Genes·Veena UnnikrishnanJacob Thundathil
Aug 31, 2021·Computational Biology and Chemistry·Neda Daei-FarshbafMehrdad Bakhtiyari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.