Sperm epigenetics and aging

Translational Andrology and Urology
T G JenkinsD T Carrell

Abstract

Advanced paternal age has very real consequences in fertility, embryogenesis, and even offspring health. Specifically, advanced paternal age has been linked to delayed time to pregnancy and in some studies even appears to be linked to a decreased likelihood of achieving a pregnancy. Epidemiological and animal model evidence also suggests that the offspring of older fathers are at an elevated risk for neuropsychiatric disease. For these reasons it is essential that we have a comprehensive understanding of what actually occurs in the gametes of the aging male. Available data suggest that there are very clear patterns of aging in the sperm epigenome that can be directly detected in DNA methylation patterns. Importantly, these alterations are so consistent that a predictive model has been successfully generated to predict an individual's age based only on sperm DNA methylation signatures. Because this metric is the most direct way to detect aging in sperm, it is logical that these signatures may offer predictive value for the offspring abnormalities that are also correlated with advanced paternal age and as such may offer a unique opportunity to generate diagnostic tools that can identify personalized risks for each couple hoping t...Continue Reading

Citations

Jan 23, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Jonathan P EvansFrancisco Garcia-Gonzalez
Apr 29, 2019·Chromosoma·Peera Wasserzug-Pash, Michael Klutstein
Apr 10, 2021·International Journal of Biometeorology·Gustavo Luis VerónMónica Hebe Vazquez-Levin
Jul 31, 2021·Human Reproduction Update·Lidiia ZhytnikAndres Salumets

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Methods Mentioned

BETA
methylation profiling

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