Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)

Human Reproduction
Miluse VozdovaJiri Rubes

Abstract

Alanced translocations are associated with infertility, spontaneous abortions and birth defects. We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 in sperm from three men who are carriers of two different translocations involving chromosomes 11 and 18. A control group comprised ten young, healthy normospermic men. The higher prevalence of alternate segregation followed by adjacent 1, adjacent 2 and 3:1, and other segregants was observed in all three patients. Two carriers of the same translocation differed only in the frequency of adjacent 2 segregation (P < 0.01). The carrier of the other translocation showed significantly higher frequency of alternate (P < 0.01) and less adjacent 1 and 3:1 segregation products (P < 0.01). An increased frequency of XY (P < 0.01), YY (P < 0.05) and diploid (P < 0.01) sperm was also detected in the group of translocation carriers compared with the control group. This difference was caused by elevated frequencies of disomy and diploidy in two of our carriers. The incidence of chromosomally unbalanced or aneuploid gametes varies in the individual translocation carriers even if the same chromosome...Continue Reading

Citations

May 4, 2010·Asian Journal of Andrology·Marumudi Eunice, Ariachery Chinnama Ammini
Jun 7, 2008·Human Reproduction Update·R H Martin
Nov 12, 2014·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Catalina ManieuSoledad Berríos
May 1, 2012·Systems Biology in Reproductive Medicine·Attila MokánszkiÉva Oláh
Nov 19, 2011·Systems Biology in Reproductive Medicine·Ester AntonJoan Blanco
Nov 26, 2011·Reproductive Biomedicine Online·Yinghui YeFan Jin
May 13, 2011·Fertility and Sterility·Miluse VozdovaJiri Rubes
Apr 6, 2011·American Journal of Medical Genetics. Part a·Miluse VozdovaJiri Rubes
Nov 25, 2020·Journal of Assisted Reproduction and Genetics·Caixia LeiXiaoxi Sun

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