PMID: 7085887Jul 1, 1982Paper

Sperm-related antigens, antibodies, and circulating immune complexes in sera of recently vasectomized men

The Journal of Clinical Investigation
S S WitkinN K Day

Abstract

Sera from 35 men were collected before and at timed intervals subsequent to vasectomy and examined for the presence of (a) antibody reactive with human spermatozoa, (b) sperm-related antigen, and (c) circulating immune complexes (CIC). Fewer than 10% of the men examined were ever positive for antisperm antibodies. However, sperm-related antigens were elevated in the sera of 18, 18, and 26% of the mean at 2 wk, 2 mo, and 4 mo postvasectomy, respectively. CIC were detected in the sera of some vasectomized men by three different assays. The CIC in patients' sera were precipitated with polyethylene glycol, dissociated, and the individual CIC components identified by an enzyme-linked immunosorbent assay. Most, but not all, of the CIC contained antigen reactive with antisperm immunoglobulin (Ig)G and some also contained complement components C3 and/or Clq. IgA was identified in some of the CIC positive for IgG and sperm antigen and two men had IgM-containing CIC. Analysis of the CIC by sucrose gradient centrifugation revealed them to be heterogeneous in size.

References

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Jan 1, 1981·The Journal of Clinical Investigation·S S WitkinN K Day
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Citations

Sep 27, 1986·Journal of Immunological Methods·M Gripenberg, P Kurki
Feb 1, 1984·Journal of Reproductive Immunology·M G O'RandN J Alexander
Mar 1, 1990·Journal of Reproductive Immunology·H H HandleyJ C Herr
Dec 1, 1990·International Journal of Andrology·P Thonneau, B D'Isle
Mar 1, 1994·American Journal of Reproductive Immunology : AJRI·A HeidenreichU H Engelmann
Feb 1, 1989·Experimental and Molecular Pathology·K W Weingand
Feb 1, 1986·Experimental and Molecular Pathology·T B ClarksonJ C Lewis
Jan 1, 1993·Journal of Clinical Epidemiology·J P MulloolyD L Fulgham
Jan 1, 1984·Annals of the New York Academy of Sciences·J I WallaceL Rogozinski
Jan 1, 1984·Annals of the New York Academy of Sciences·C E MetrokaS S Witkin
Sep 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·L A Eng, C B Metz
Jul 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·J C HerrT N Gallien
Oct 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·N J AlexanderS S Witkin

Related Concepts

Antibody Specificity
Immune complex
Antigens
Autoantibodies
Autoantigens
Bos indicus
Centrifugation, Density Gradient
Enzyme-Linked Immunosorbent Assay
Polyglobin
Y-Chromosome-Bearing Sperm

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