Sperm selection methods in the 21st century

Biology of Reproduction
Denis A Vaughan, Denny Sakkas

Abstract

Natural sperm selection in humans is a rigorous process resulting in the highest quality sperm reaching, and having an opportunity to fertilize, the oocyte. Relative to other mammalian species, the human ejaculate consists of a heterogeneous pool of sperm, varying in characteristics such as shape, size and motility. Semen preparation in assisted reproductive technologies (ART) has long been performed using either a simple swim up method or density gradients. Both methodologies provide highly motile sperm populations, however neither replicate the complex selection processes seen in nature. A number of methods have now been developed to mimic some of the natural selection processes that exist in the female reproductive tract. These methods attempt to select a better individual, or population of, spermatozoa when compared to classical methods of preparation. Of the approaches already tested, platforms based upon sperm membrane markers, such as hyaluronan or annexin V, have been used to either select or deselect sperm with varied success. One technology that utilizes the size, motility and other characteristics of sperm to improve both semen analysis and sperm selection is microfluidics. Here, we sought to review the efficacy of b...Continue Reading

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Citations

Dec 12, 2020·Andrology·Kazuko OgataKenichi Yamashita
Mar 5, 2021·Journal of Assisted Reproduction and Genetics·Sandra Lara-CerrilloAgustín García-Peiró
Apr 1, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Cindy Rivas ArzaluzAndrés Aragón Martínez
Jun 22, 2021·Fertility and Sterility·Alison CampbellCarlos Simon
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anand Baby AliasDa-Jeng Yao
Jul 28, 2021·Zygote : the Biology of Gametes and Early Embryos·A PujolR Vassena
Aug 22, 2021·Journal of Assisted Reproduction and Genetics·Angela Q LeungDenny Sakkas
Apr 15, 2021·Endocrinology·Vedant V Bodke, Joanna E Burdette
Aug 28, 2021·Cells·Francesco ManfrevolaRosanna Chianese

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