Spermadhesin PSP-I/PSP-II heterodimer induces migration of polymorphonuclear neutrophils into the uterine cavity of the sow

Journal of Reproductive Immunology
H Rodríguez-MartínezJ J Calvete

Abstract

Seminal plasma (SP) is a complex fluid which exerts biological actions in the female reproductive tract. In pigs, SP elicits endometrial inflammation and consequent immune changes after mating. This study tested whether heparin-binding spermadhesins (HBPs) and the heterodimer of porcine sperm adhesions I and II (PSP-I/PSP-II) in SP recruit different lymphocyte subsets (CD2(+), CD4(+) and CD8(+) T cells) or polymorphonuclear leukocytes (PMNs) to the superficial endometrium or luminal epithelium and lumen, respectively, of oestrous sows. In Experiment 1, endometrial biopsies were taken between 2 and 120 min after infusion of uterine horns with HBPs, PSP-I/PSP-II or saline and evaluated by immunohistochemistry or histology. In Experiment 2, the uterus of oestrous sows was infused with PSP-I/PSP-II or saline to assess PMN numbers in the uterine lumen 3h later. PSP-I/PSP-II elicited CD2+ T cell recruitment from 10 min, and CD8(+) T cells from 60 min after infusion, while HBPs increased CD4(+) T cell recruitment by 120 min. PSP-I/PSP-II but not HBPs induced PMN migration to the surface epithelium by 10 min. PMN numbers were elevated 5-fold by 30 min and 7-fold from 60 min, with PMNs detectable in the lumen from 30 min after infusion....Continue Reading

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Citations

Jan 15, 2011·Journal of Assisted Reproduction and Genetics·Ronald H F HunterD Rath
Oct 29, 2009·The Journal of Reproduction and Development·Margareta WallgrenHeriberto Rodriguez-Martinez
Oct 23, 2012·Systems Biology in Reproductive Medicine·Alfonso López RodríguezDominiek Maes
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Aug 29, 2012·Reproduction in Domestic Animals = Zuchthygiene·T Katila
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Jan 20, 2017·BMC Genomics·Mohammad AtikuzzamanHeriberto Rodriguez-Martinez
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Feb 24, 2020·Theriogenology·Jordi RocaInmaculada Parrilla
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Nov 26, 2021·Frontiers in Cell and Developmental Biology·Yaqun DingLi Jiang

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